Moonlighting from sugar to metal

该项目旨在利用综合遗传学、生物化学和组学来破译高度保守的OST 3蛋白的作用，这些蛋白与调节蛋白质糖基化和转运镁的不同功能有关。该项目计划详细说明OST 3蛋白在调节哺乳动物糖基化中的作用，并重建OST 3蛋白-底物相互作用的脊椎动物共进化轨迹。它还旨在确定和验证OST 3蛋白介导的镁转运的调节，机制和代谢后果。这些结果可能会提供深入了解真核生物学，并允许糖蛋白生产和调节细胞代谢的工程系统的进展，具有潜在的研究和治疗效用。

This project intends to use integrated genetics, biochemistry and omics to decipher the roles of the highly conserved OST3 proteins, which have been implicated in the disparate functions of regulating protein glycosylation and transporting magnesium. The project plans to detail the role of OST3 proteins in regulating mammalian glycosylation and reconstruct the vertebrate co-evolutionary trajectory of OST3 protein–substrate interactions. It also aims to identify and characterise the regulation, mechanisms and metabolic consequences of OST3 protein-mediated magnesium transport. These outcomes may provide insights into eukaryotic biology, and allow advances in engineered systems for glycoprotein production and modulating cellular metabolism with potential research and therapeutic utility.