CAREER:Bio-electro-photonic Microsystem Interfaces for Small Animals

提案编号：ECCS-1554367提案标题：Career：用于小动物的生物电-光子微系统接口PI名称：Bozkurt，Alper Y.机构：北卡罗来纳州立大学目的：研究人员提出一种无线供电的可注射胶囊，能够监测生物潜力和生物光子生理信号，包括心率、呼吸频率、血氧饱和度、脉搏通过时间和核心体温。拟议的调查包括完整的系统集成和广泛的评估。非技术摘要：仿生微系统的新兴领域为解决现实生活中的问题提供了新的工程机会。通过将生物有机体与合成电子系统融合在一起，我们可以在永恒的工程斗争中实现量子飞跃，以模拟生物机器相对更复杂的属性，如在不同长度尺度上观察到的自主性、智能性和生物复杂性。该项目的目标是克服实现这一成就的主要技术障碍，即提供有关生物有机体状态的实时信息的最先进接口的低效。拟议的微系统将打开一扇生理学之窗，以提高对小动物在自然环境中的生理学的了解。该项目独特的跨学科和动手性质将帮助我们接触到所有公民，包括男女、代表不足的少数群体和残疾人，并培训他们使用生物电子学、生物光子学和可穿戴的无线生理系统。此外，我们还将设计其他模块，包括演示、展示和展示，以及设计竞赛。我们还将使用它们来开发新的课程和实验模块。我们将通过与当地博物馆的合作，与广大公众接触。在这些活动中，我们将利用我们在国内和国际知名媒体机构进行媒体报道和持续互动的成功记录。技术摘要：我们的长期目标是实现基于微系统的平台，在小动物身上进行各种生理测量。通过这样做，我们可以满足对一种新型微创系统的迫切需求，这种系统可以在不干扰自然行为的情况下连续记录自然环境中的关键生理参数。为了应对此类系统更高功耗的挑战，我们将(A)受益于皮下测量的优势，(B)设计可通过多种策略降低功耗的定制前端电路。为了在超小型化外形中实现多种生理参数的无线评估，微系统将包括最先进的电路方法、无线电力和通信系统以及带有挤压电极的密封包装。该系统的有效性将在四个平台的试验台上进行评估：(A)使用计算模型在硅胶中进行评估；(B)使用组织模体进行体外评估；(C)使用动物身体进行体外评估；以及(D)使用大鼠模型进行体内评估。

Proposal Number: ECCS - 1554367 Proposal Title: CAREER: Bio-electro-photonic Microsystem Interfaces for Small AnimalsPI Name: Bozkurt, Alper Y. Institution: North Carolina State UniversityObjective:The investigator proposes a wirelessly powered injectable capsule capable of monitoring bio-potentials and bio-photonic physiological signals including heart rate, respiration rate, oxygen saturation, pulse transit time and core body temperature. The proposed investigation includes a complete system integration and extensive evaluation. Non-technical Abstract: The emerging field of Bionic MicroSystems offers new engineering opportunities to solve real life problems. By fusing biological organisms with synthetic electronic systems, a quantum leap can be enabled in our ever-lasting engineering struggle to mimic relatively more complicated properties of biological machines, such as autonomy, intelligence, and biocomplexity observed across various length scales. This project targets to overcome major technical barrier in the way of such achievement, which is the inefficiency of state-of-art interfaces that would provide real-time information about the state of the biological organism. The proposed microsystem will open a physiological window to improve understanding of the physiology of small animals in their natural environment. The unique interdisciplinary and hands-on nature of this project will help us to reach out to all citizens"women and men, underrepresented minorities, and persons with disabilities"and train them to use bioelectronics, biophotonics, and wearable wireless physiological systems. Further, we will design other modules including presentations, show and tell displays, and design contests. We will also use these to develop a new course and lab modules. We will engage with the public at large by means of our collaboration with local museums. In these activities, we will leverage our successful track record of media coverage by and continuing interaction with prominent national and international media agencies.Technical Abstract: Our long term goal is to enable microsystem based platforms that would perform various physiological measurements wirelessly in small animals. In doing so, we can respond to the critical need for a novel minimally invasive class of systems for continuous recording of key physiological parameters in natural environments without disturbing natural behavior. To address the challenge of higher power consumption of such systems, we will (a) benefit from the advantages of subcutaneous measurements and (b) design custom front-end circuits that would reduce power consumption through multiple strategies. To enable wireless assessment of multiple physiological parameters in ultra-miniaturized form factors, the microsystems will include state-of-the-art circuit approaches, wireless power and communication systems, and sealed packaging with extruding electrodes. The efficacy of the system will be assessed on a four platform testbed: (a) in silico using a computational model, (b) in vitro using a tissue phantom, (c) ex vivo using animal cadavers, and (d) in vivo using rat models.