CAREER: Harnessing the reactivity of neutral aminyl radicals for complex heterocycle synthesis

通过这个职业奖的化学合成计划在化学部支持教授詹妮弗L。韦恩州立大学的斯托克迪尔。斯托克迪尔教授正在研究形成不寻常化学结构的反应。该项目提供了一种新的方法来制备具有碳和氮原子的环状结构（杂环），包括具有多种生物活性的分子，如血管舒张剂，细胞毒性和神经活性。在她的项目的教育部分，教授Stockdill正在开发一个推广计划，重点是提高妇女和少数民族在科学。 通过她的研究计划，研究生和本科生接受研究实践培训。 外联活动向中学女生传授基本的有机化学概念，向她们灌输科学发现的热情，无论她们最终是否从事科学事业。 此外，教授Stockdill与Alchemie合作开发新的活动，帮助学习具有挑战性的有机化学概念，她为现有的本科和研究生课程创建了新的主动学习模块。Stockdill教授正在研究使用中性氨基自由基的新型环化反应。这些反应性实体具有快速组装复杂分子的潜力，这可能对一系列后续应用有用。中性胺基自由基由于其不可预测的反应性，以前没有被广泛应用于合成序列。Stockdill博士正在测试一个关于互补自由基受体的必要性质的假设，以及开发避免使用有毒试剂的氨基自由基生成方法。该项目提供了获得各种已知的和新颖的杂环分子具有不同的生物活性。这项研究也为中性胺基自由基的反应性提供了新的认识，使多环杂环的快速组装成为可能。化学家可预测地采用的新反应方法的开发广泛地有助于改善可用于筛选文库的化学空间的范围。最终，获得新的分子可能使分子结构的鉴定成为可能，这些分子结构可以探测基本的生物学功能，并可能在制药应用中作为主要靶标。 本科生和研究生在Stockdill实验室接受有机化学和科学方法的培训。 Stockdill博士还创建了一个女科学家网络，通过发展一个研究生妇女在科学（GWIS）组，使妇女可以找到他们需要的支持，在研究生院取得成功，并在整个科学生涯。

Through this CAREER Award the Chemical Synthesis Program in the Chemistry Division is supporting the research program of Professor Jennifer L. Stockdill of Wayne State University. Professor Stockdill is investigating reactions to form unusual chemical structures. This project provides a new method to prepare ring structures with carbon and nitrogen atoms (heterocycles), including molecules with a diverse set of biological actions such as vasorelaxant, cytotoxic, and neurologic activity. In the educational component of her project, Professor Stockdill is developing an outreach program centered on advancing women and minorities in science. Through her research program, graduate and undergraduate students receive hands-on training in research. The outreach activities teach basic organic chemistry concepts to middle school girls, instilling in them an enthusiasm for scientific discovery, whether they ultimately pursue a career in science or not. Additionally, Professor Stockdill collaborates with Alchemie to develop new activities that aid in learning challenging organic chemistry concepts, and she creates new active learning modules for existing undergraduate and graduate courses. Professor Stockdill is investigating novel cyclization reactions employing neutral aminyl radicals. These reactive entities have potential for the rapid assembly of complex molecules that may be useful for a range of subsequent applications. Neutral aminyl radicals have not previously been widely applied in synthetic sequences because of their unpredictable reactivity. Dr. Stockdill is testing a hypothesis regarding the necessary properties of the complimentary radical acceptors, as well as developing methods for aminyl radical generation that avoid the use of toxic reagents. This project provides access to a variety of both known and novel heterocyclic molecules with a diverse set of bioactivities. This research also provides new understanding of the reactivity of neutral aminyl radicals, enabling the rapid assembly of polycyclic heterocycles. The development of new reaction methods that can be employed predictably by chemists contributes broadly to improving the scope of chemical space available for screening libraries. Ultimately, access to new molecules may enable the identification of molecular structures that probe fundamental biological functions and potentially serve as lead targets in pharmaceutical applications. Undergraduate and graduate student are trained in organic chemistry and the scientific method in the Stockdill laboratory. Dr. Stockdill also creates a network of female scientists through the development of a Graduate Women in Science (GWIS) group, so that women can find the support they need to be successful in graduate school and throughout their careers in science.