REU Site: Penn State Cardiovascular Research: Engineering A Translational Experience (CREATE)

宾夕法尼亚州立大学-大学公园的本科生研究经验（REU）站点，题为宾夕法尼亚州立大学心血管研究：工程转化经验（CREATE），将使学生接触研究，阐明控制生物反应的细胞/分子过程，用于心血管疾病（CVD）和治疗性CVD干预措施的发展。由于两个原因，对心血管疾病（CVD）教育的关注是极其重要和高度相关的。首先，心血管疾病仍然是美国的头号杀手。因此，非常需要培养一批新的工程师和科学家，他们可以成为检测、预防和治疗这种疾病的领导者。其次，心血管疾病的潜在病因及其相关技术结合起来，形成了一个完美的培训平台，以培养创造性和综合性思维，这是生物医学工程的标志。该计划的目标是：1)开展多尺度问题的研究，以提高对心血管疾病的理解和治疗，2)应用创造性的过程来解决应用于心血管疾病治疗或干预的工程问题，3)能够描述将研究转化为市场技术的过程，4)能够识别在研究生和专业学校取得成功的要求。在三年的时间里，这个REU项目将让本科生参与为期10周的暑期密集实践研究和专业发展/培训经验，在那里他们将熟练掌握生物医学工程中的细胞/分子工程、显微镜或计算方法的基本概念和实践，同时整合理解CVD的创作过程。该计划将包括与教师研究导师的个人研究项目、安全培训、研究需求和负责任的研究行为研讨会、应用于研究、医疗设备开发和知识产权的创造性过程讲习班、推广/传播学生研究成果以及研究专题讨论会。通过这些活动，宾夕法尼亚州立大学创新学院将为年轻的研究人员提供新的研究途径，定量和分析方法的新技术，以及新的医学诊断和介入工具的新机会。

This Research Experiences for Undergraduates (REU) Site at Pennsylvania State University-University Park, entitled Penn State Cardiovascular Research: Engineering A Translational Experience (CREATE)," will expose students to research that will elucidate cellular/molecular processes governing biological responses to materials as applied to cardiovascular disease (CVD) and the development of therapeutic CVD interventions. This focus on education in cardiovascular disease (CVD) is extremely important and highly relevant for two reasons. First, CVD remains the number one killer in the United States. Thus, there is a great need to develop a pipeline of new engineers and scientists who can become leaders in the detection, prevention, and treatment of the disease. Second, the underlying etiology of CVD and its associated technologies combine to form a perfect platform for training in the creative and integrative thinking that is the hallmark of biomedical engineering. The objectives of this program are: 1) To conduct research on multi-scale problems to improve the understanding and treatment of CVD, 2) To apply the creative process to solve engineering problems applied to CVD treatment or intervention, 3) To be able to describe the process of translating research into marketable technology, and 4) To be able to identify requirements for success in graduate and professional schools. Over a three year period, this REU program will engage undergraduate students in a 10-week intensive hands-on summer research and professional development/training experience, where they will develop proficiency in the underlying concepts and practice of cellular/molecular engineering, microscopy, or computational methods in biomedical engineering while integrating the creative process towards understanding CVD. The program will include individual research projects with faculty research mentors, seminars on safety training, research needs, and responsible conduct of research, workshops on the creative process applied to research, medical device development and intellectual property, outreach/dissemination of student research, and a research symposium. Through these activities Penn State CREATE will provide young researchers with new avenues of investigation, new technologies in quantitative and analytical methods, and new opportunities in novel diagnostic and interventional tools in medicine.