Phantom polyguanidines by ring-closing condensation polymerization: Mechanistic studies and properties investigations

环聚胍是该提案的重点。该项目的目的是获得一种新型的幻影闭环聚合的合成环聚胍的基本了解，并详细研究其性能的应用领域之一，例如，作为抗菌聚合物。通过二胺与盐酸胍的反应合成的线性聚胍是已知的。相反，环聚胍在文献中是未知的。建议的假设是，通过选择用于与盐酸胍的缩聚的适当单体（即合适的胺），可以合成以其他方式不可得的新的环结构。在亲核加成反应中伯胺和仲胺的不同反应性与缩合过程中适当的相反阴离子组合，预期提供在重复单元中具有环结构的幻影聚合物。胍盐中阴离子的类型也可以通过改变过渡态的几何形状和稳定性来控制最终聚合物结构。为了实现这一目标，提出了在不同的均聚和共聚缩合反应条件下使用各种胺的实验和量子化学计算。 考虑到我们的目标，该项目的预期成果将是在理论和实验中的结构，性质（热，抗菌和细胞毒性）和机械方面的一个良好表征的新的聚胍子类。

Ring-polyguanidines are in the focus of this proposal. The objective of the proposed project is to get basic understanding of a new type of phantom ring-closing polymerization for the synthesis of ring polyguanidines and investigate their properties in details in one of the application areas, for example, as antibacterial polymers. Linear polyguanidines synthesized by the reaction of diamines with guanidine hydrochloride are known. In contrary, ring polyguanidines are not known in the literature. The hypothesis of proposal is that by choice of appropriate monomers (i.e. suitable amines) for condensation polymerization with guanidine hydrochloride, novel ring structures can be synthesized which are otherwise not accessible. The different reactivities of primary and secondary amines in nucleophilic addition reactions in combination with the appropriate opposite anion during condensation are expected to provide phantom polymers with ring structures in the repeat unit. The type of anion in guanidine salt could also play a major role in controlling the final polymer structure by changing the geometry and stability of the transition states. Experiments using various amines under different condensation reaction conditions of homo- and copolymerizations and quantum chemical calculations are proposed to achieve the objectives. Keeping-in-view our objectives, the expected outcome of the project would be a well-characterised new sub-class of polyguanidines in terms of structure, properties (thermal, antibacterial and cytotoxicity) and mechanistic aspects in theory and experiment.