Electrospun polymer nonwovens as highly functional substrates for advanced applications in waste water treatment and medical applications

静电纺聚合物非织造布作为高功能基材，用于废水处理和医疗应用的高级应用

• 批准号: 235690896
• 负责人: Professorin Dr. Seema Agarwal
• 金额: --
• 依托单位: Department of Microbiology and Molecular Genetics
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/235690896?language=en
• 关键词: Electrospun; polymer; nonwovens; highly; functional

The topic of this trilateral research project of an international interdisciplinary research team is the investigation of electrospun polymer nanofiber nonwovens as functional carriers for biological agents (bacteria and drugs). The motivation for these investigations is the basic understanding of the active role of electrospun polymer nanofiber nonwovens as carriers for biological agents and probing of these results for solutions for actual related problems. The basic hypothesis of the project is that sustainable preservation of the function of biological agents in electrospun nonwovens is possible for various related applications. Significantly better performance of composites of electrospun polymer nonwoven / biological agents as compared to pure agents (microbes and drugs) is expected due to responsive and selective hybrid configuration and due to protection of the active biological agents under adverse environmental conditions. For this model research are suggested as biologically active substances bacteria for waste water treatment of olive oil mill liquid waste and drugs for the treatment of parasite-based disease like leishmaniasis and malaria. The flexibility in the design of polymer systems and electrospun nanofiber nonwovens should be an ideal platform for the preparation of novel hybrid systems to provide answers for questions to the role of eletrospun nonwovens. The expected outcome of this project will be an answer to the question of whether electrospun polymer nonwovens as carriers for biologically active agents will provide significant advantages or not. This answer will be verified on concrete applications of waste water treatment and therapy for parasite diseases.

这个国际跨学科研究团队的三边研究项目的主题是研究静电纺丝聚合物无纺布作为生物制剂（细菌和药物）的功能载体。这些调查的动机是对静电纺聚合物无纺布作为生物制剂载体的积极作用的基本理解，并探索这些结果，以解决实际相关问题。该项目的基本假设是，静电纺非织造布中生物制剂功能的可持续保护对于各种相关应用是可能的。与纯试剂（微生物和药物）相比，预期电纺聚合物非织造物/生物试剂的复合材料的显著更好的性能是由于响应性和选择性混合构型以及由于在不利环境条件下对活性生物试剂的保护。对于这个模型的研究建议作为生物活性物质的细菌的废水处理橄榄油厂液体废物和药物治疗寄生虫为基础的疾病，如利什曼病和疟疾。聚合物系统和静电纺丝非织造布设计的灵活性应该是制备新型混合系统的理想平台，为静电纺丝非织造布的作用问题提供答案。该项目的预期成果将回答静电纺聚合物非织造布作为生物活性剂载体是否具有显著优势的问题。这个答案将在废水处理和寄生虫病治疗的具体应用中得到验证。

项目成果

Electrospun Nimodipine-loaded fibers for nerve regeneration: development and in vitro performance.

• DOI: 10.1016/j.ejpb.2020.03.021
• 发表时间: 2020-04
• 期刊: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
• 作者: Johanna Zech;S. Leisz;Benedikt Göttel;F. Syrowatka;A. Greiner;C. Strauss;W. Knolle;C. Scheller;K. Mäder

Controlled and manageable release of antimalarial Artemisone by encapsulation in biodegradable carriers

• DOI: 10.1016/j.eurpolymj.2020.109625
• 发表时间: 2020-04-15
• 期刊: EUROPEAN POLYMER JOURNAL
• 影响因子: 6
• 作者: Bagheri, Amir Reza;Golenser, Jacob;Greiner, Andreas
• 通讯作者: Greiner, Andreas

Unlocking Nanocarriers for the Programmed Release of Antimalarial Drugs

• DOI: 10.1002/gch2.201600011
• 发表时间: 2017-01
• 期刊: Global Challenges
• 影响因子: 4.9
• 作者: A. Bagheri;S. Agarwal;J. Golenser;A. Greiner

Isolation and characterization of phenol degrading bacterium strain Bacillus thuringiensis J20 from olive waste in Palestine

• DOI: 10.1080/10934529.2017.1368300
• 发表时间: 2018-01-01
• 期刊: JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
• 影响因子: 2.1
• 作者: Ereqat, Suheir I.;Abdelkader, Ahmad A.;Abdeen, Ziad A.
• 通讯作者: Abdeen, Ziad A.

High-Temperature Spray-Dried Polymer/Bacteria Microparticles for Electrospinning of Composite Nonwovens.

用于复合非织造布静电纺丝的高温喷雾干燥聚合物/细菌微粒

• DOI: 10.1002/mabi.201800356
• 发表时间: 2019
• 期刊: Macromolecular bioscience
• 影响因子: 4.6
• 作者: Kaiser;Schmalz;Rhinow;Freitag;Greiner
• 通讯作者: Greiner