Variation in cardioviruses in rats and Microcebus griseorufus as a rodent-primate model for interspecific transmission of viruses

本研究的目的是分析鼠类和灵长类动物灰鼠体内心脏病毒和肠道病毒的空间和季节变化。此外，我们还调查了灵长类动物直接感染啮齿动物病毒的证据，以及与之相关的种群模式。根据寄主生物体的空间、时间和生理模式，我们将提出关于接触强度在病毒种间传播中的作用的假设。我们预计，无论是通过直接病毒检测还是通过血清学，零星传播的证据都是可以检测到的，但一旦获得，病毒在灵长类动物中的维持将取决于进一步的种群依赖参数，如群体密度或特定的物理条件，如年龄和繁殖。这一啮齿动物-灵长类动物模型的结果也将对人类健康的土地利用管理和维护特有物种的保护管理具有重要意义。

The goal of this study is to analyse spatial and seasonal variation in cardioviruses and enteroviruses in rats (Rattus rattus) and the primate Microcebus griseorufus. In addition we investigate the evidence of direct acquisition of rodent viruses by primates, as well as the population patterns associated with it. Based on the spatial, temporal, and physiological pattern of the host organisms we will formulate hypotheses on the role of contact intensity for interspecific transmission of viruses. We expect that evidence for sporadic transmission, either by direct virus detection or by serology, will be detectable but that the maintenance of virus in primates, once acquired, will depend on further population-dependent parameters such as group density or specific physical conditions such as age and reproduction. The results of this rodent – primate model will also be of relevance for land use management for human health and conservation management to maintain endemic species.