Role of Trib1 in Obesity and Metabolism – Tissue Specific Effects and Target Molecules (B07+)

tribles同源基因1 （Trib1）是最近发现的与脂质代谢和动脉粥样硬化相关的基因之一。鉴于Trib1缺失小鼠的白色脂肪组织和骨骼肌中观察到显著的代谢变化，该项目采用条件敲除策略来制造脂肪组织和骨骼肌中特异性缺乏Trib1的小鼠。这些模型的代谢和功能特征将阐明trib1消耗如何改善胰岛素敏感性、肥胖相关的脂肪组织功能障碍和骨骼肌中的异位脂肪沉积。

The gene tribbles homolog-1 (Trib1) was recently identified as one of the genes related to lipid metabolism and atherosclerosis. Given the observed significant metabolic changes in white adipose tissue and skeletal muscle of Trib1-deficient mice, the projects applies conditional knockout strategies to create mice specifically lacking Trib1 in adipose tissue and skeletal muscle. Metabolic and functional characterization of these models will elucidate how Trib1-depletion ameliorates insulin sensitivity, obesity associated adipose tissue dysfunction and ectopic fat deposition in skeletal muscle.