Assessing the physiological roles of ubiquitination in regulating neuronal ion channels, receptors and transporters

在组织损伤和再生以及许多神经退行性疾病状态中，神经元转运体和受体的活动发生显著改变。调控这些转运蛋白的途径是一个新兴的治疗靶点，然而，这些控制机制的分子基础仍然知之甚少。该项目的结果将是对神经元中一种新的调控范式的全面描述，这可能对神经元的发育和再生至关重要，并可能为各种神经元疾病提供新的治疗靶点。

Significant alterations in the activity neuronal transporters and receptors occur during tissue injury and regeneration as well as in many neurodegenerative disease states. Modulation of the pathways that control these transporters is an emerging therapeutic target, however, the molecular basis of these control mechanisms remain poorly understood. The outcome of this project will be a thorough characterisation of a novel regulatory paradigm in neurons that is likely to be crucial for neuronal development and regeneration, and will potentially provide novel therapeutic targets for various neuronal diseases.