Circular Plant Proteins with Pharmaceutical Applications

这项研究将开发利用植物作为蛋白质生产工厂的方法。最初，我将使用植物来制造工程化的环肽，这些环肽包含对癌症和多发性硬化症具有有效治疗活性的肽。在植物中成功生产治疗性蛋白质将使这些疾病和其他疾病的治疗更容易获得，从而使澳大利亚人受益。它也有可能从澳大利亚药物的销售中获得重大经济利益。该提案还将为研究生提供多学科方法的优秀研究培训，这些方法构成了最先进的结构和植物分子生物学。

The proposed research will develop methods for using plants as protein production factories. Initially I will use plants to create engineered cyclotides that incorporate peptides with proven therapeutic activity against cancer and multiple sclerosis. Successful production of therapeutic proteins in plants will benefit Australians by making treatments for these and other diseases more accessible. It also has the potential for a major economic benefit from the sales of Australian-based drugs. This proposal will also provide outstanding research training for graduate students in multidisciplinary methods that constitute state-of the-art structural and plant molecular biology.