Buried treasure: bioactive plant seed proteins evolving inside hosts

埋藏的宝藏：生物活性植物种子蛋白在宿主体内进化

• 批准号: DP190102058
• 负责人: Prof Joshua Mylne
• 金额: $ 29.63万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102058
• 关键词: Buried; treasure; bioactive; plant; seed

This project aims to examine how evolution in plants shortcuts the creation of new proteins by burying one within another. Scientists now realise that new genes and proteins appear frequently. A recent discovery in plant seeds involves DNA sequence insertions in a gene that makes two proteins instead of one. This project will reveal a new family of buried seed proteins, determine the rules for burying them and search plants for new examples. The first examples from plants create strongly bioactive products so the ability to dig for similar plant events will reveal new and bioactive natural products with biomedical and biotechnology applications.

该项目旨在研究植物的进化如何通过将一种蛋白质埋在另一种蛋白质中来缩短新蛋白质的产生。科学家们现在意识到，新的基因和蛋白质经常出现。最近在植物种子中的一项发现涉及在一个基因中插入DNA序列，该基因产生两种蛋白质而不是一种。该项目将揭示一个新的埋藏种子蛋白家族，确定埋藏它们的规则，并在植物中寻找新的例子。来自植物的第一个例子创造了强烈的生物活性产品，因此挖掘类似植物事件的能力将揭示具有生物医学和生物技术应用的新的生物活性天然产品。