Bone regulation - cell interactions to disease

许多骨病，如骨质疏松症、Paget病和与骨质疏松相关的骨病，都与骨细胞间通讯通路的中断直接相关，导致骨重建的失衡。虽然这些疾病很常见，并造成相当大的痛苦，但在大多数情况下，人们对功能失调性重塑的机制知之甚少。了解骨细胞之间的通讯网络及其与药物的相互作用对于开发新的治疗方法和有效地设计新型生物相容性骨植入物是必不可少的。这项研究建议与国家研究优先事项2密切一致，即促进和保持良好的健康(良好老龄化、有成效的老龄化)。

Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their interaction with drugs is essential in order to develop new therapies and to effectively design novel biological compatible bone implants. This research proposal closely aligns with national research priority two, i.e., promoting and maintaining good health (ageing well, ageing productively).