Functional impact of clock genes on circadian timing of metabolism: a metabolomics approach (A04)

该项目将采用代谢组学方法研究中枢和脂肪生物钟对代谢时间的功能影响。在已经确定的振荡代谢物的基础上，我们的目标是澄清这些代谢物是否以昼夜节律方式调节，并研究大脑和脂肪体中的分子钟对代谢振荡的影响。在中央和脂肪生物钟不同步后，生物钟紊乱的代谢后果将被分析。生物钟在调节摄食行为和生理代谢方面的功能意义将在另一个工作包中进行测试。在CRC中，A4也将作为中心代谢物分析和代谢组学的核心单位。

The project will study the functional impact of the central and fat body clock on the timing of metabolism by taking a metabolomics approach. Building on the already identified oscillating metabolites, we aim to clarify whether these metabolites are regulated in a circadian fashion and study the impact of the molecular clock in the brain and the fat body on metabolic oscillations. After desynchronization of the central and fat body clocks, the metabolic consequences of the disturbed clockwork will be analyzed. The functional significance of circadian clocks for adjusting feeding behavior and metabolism to the physiological optimum will be tested in another work package. Within the CRC, A4 will also function as a central metabolite analysis and metabolomics core unit.