I-Corps: Vivid Microscopy LLC: Imaging Thiols to Understand Oxidative Stress

这个I-Corps项目的更广泛的影响/商业潜力将帮助疾病研究人员更好地了解氧化应激如何影响各种疾病状态。 具体来说，我们的产品将显示癌症和阿尔茨海默氏症等疾病如何随着时间的推移而进展，最重要的是，如何更有效地治疗这些疾病。 初步研究表明，我们提出的产品之一可以区分拟议的阿尔茨海默氏症药物的有效性，进行蛋白质研究，成像二硫醇，并通过测定谷胱甘肽来量化氧化应激。 这个I-Corps项目的重点是确定这些产品在生物技术研究市场中的适销性，确定市场规模，并深入了解氧化应激市场的竞争格局。 通过这种理解，我们将确保我们的产品满足市场需求，并在必要时能够更好地根据客户需求定制我们的产品。 由于该项目提供了改善氧化应激研究的机会，也可用于区分疾病状态，该公司的潜在产品将产生重大的商业和社会影响。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project will help disease researchers better understand how oxidative stress impacts a variety of disease states. Specifically, our products will show how illnesses such as cancer and Alzehimer's progress over time and, most importantly, how to more effectively treat these conditions. Preliminary research indicates one of our proposed products can differentiate the effectiveness of a proposed Alzheimer's drug, conduct protein studies that image dithiols and quantify oxidative stress through a determination of glutathione. This I-Corps project is focused on ascertaining the marketability of these products within the biotech research market, ascertaining market size and gaining a thorough understanding of the competitive landscape of the oxidative stress market. Through this understanding, we will insure that our products fill a market need and, if necessary, can pivot to better tailor our products to customer need. As this project offers the opportunity to improve oxidative stress research and could also be used to differentiate disease states, the company's potential products offer significant commercial and societal impact.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.