FASEB Conference on "From Unfolded Proteins in the Endoplasmic Reticulum to Disease"

该项目的总体目标是通过大力鼓励研究生和博士后研究员积极参与FASEB夏季研究会议的所有方面，将研究、教育和培训结合起来。FASEB关于内质网(ER)的会议成立于2007年，以满足以ER为重点的研究会议的迫切需求。这次FASE B会议将汇集一个国际研究团体，研究内质网的结构、功能和调节。这次会议将使早期职业科学家接触到该研究领域领先实验室正在使用的广泛的实验系统和方法。强烈鼓励与会者提交海报会议摘要。除了被邀请的30位演讲者外，还将根据他们提交的海报摘要，选择另外12位演讲者进行“最新演讲”，这对研究生和博士后研究员具有强烈的偏好。本次FASEB会议的一个关键目标是在会议的所有会议期间，包括平台演讲、会议演讲者会议和职业发展研讨会，促进该领域公认的领导者和早期职业科学家之间的讨论和信息交流。FASEB关于内质网的夏季会议是应用新技术、开发新概念和促进具有互补专业知识的研究人员之间研究合作的关键推动力。通过促进更广泛地参与ER领域和培养下一代ER研究人员，实现这一项目的目标对于维持这一研究领域的可行性至关重要。这个多学科的会议汇集了由生物化学家、细胞生物学家、分子生物学家、遗传学家和生理学家组成的不同的国际社区，他们研究内质网中的蛋白质动态平衡。会议的重点是阐明生物合成的机制；内质网中蛋白质的加工和折叠；区分折叠和错折叠蛋白质的蛋白质质量控制机制；使细胞减轻蛋白质错折叠应激的内质网应激反应途径；以及保护细胞免受未折叠蛋白质聚集体在内质网中有毒积累的内质网相关降解途径。虽然在这一研究领域取得了巨大进展，但仍然存在关键的知识差距，现在可以使用以前没有的实验方法和跨学科方法来填补这些差距，以协同扩大这一研究领域的知识。上午和晚上的会议平台会议将包括受邀的发言者以及最晚的发言，分配了足够的讨论时间。午餐会见演讲者会议、下午早些时候的职业发展研讨会和下午晚些时候的海报会议将促进与会者之间的互动。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The overarching objective of the project is to integrate research, education and training by strongly encouraging the active participation of graduate students and postdoctoral fellows in all aspects of a FASEB Summer Research Conference. The FASEB conference on the Endoplasmic Reticulum (ER) was established in 2007 to fill a critical need for an ER focused research conference. This FASEB Conference will bring together an international research community that investigates the structure, function and regulation of the endoplasmic reticulum. The conference will expose early career scientists to a broad range of experimental systems and approaches that are being used by the leading laboratories in this research field. Conference attendees are strongly encouraged to submit poster session abstracts. In addition to the thirty invited speakers, twelve additional speakers will be selected for "late breaking talks" based upon their submitted poster abstracts, giving strong preference for graduate students and postdoctoral fellows. A critical objective of this FASEB conference is to stimulate discussion and the exchange of information between the established leaders in the field and early career scientists during all sessions of the meeting including the platform talks, meet the speaker sessions, and career development workshops. The FASEB summer conference on the endoplasmic reticulum is a critical driving force for the application of new technologies, development of novel concepts and fostering research collaborations between investigators with complementary expertise. Achieving the objectives of this project is critical to maintain the viability of this research field by promoting broader participation in the ER field and the development of the next generation of ER researchers. This multi-disciplinary meeting brings together a diverse international community of biochemists, cell biologists, molecular biologists, geneticists and physiologists who investigate protein homeostasis in the endoplasmic reticulum. The conference is focused on elucidating the mechanisms for biosynthesis; processing and folding of proteins in the ER; protein quality control mechanisms that discriminate between folded and misfolded proteins; ER stress response pathways that allow the cell to alleviate protein-misfolding stress; and the ER associated degradation pathway that protects cells from the toxic accumulation of unfolded protein aggregates in the ER. While there has been tremendous progress in this research field, there remain critical knowledge gaps that can now be addressed using experimental methods that were not previously available and by cross-disciplinary approaches to synergistically expand knowledge in this research field. The conference platform sessions in the morning and evening will feature the invited speakers as well as the late breaking talks, with sufficient time allocated for discussion. Meet the speaker sessions at lunch, career development workshops in the early afternoon and poster sessions in the late afternoon will facilitate interactions between meeting attendees.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.