New polymerisation processes for the synthesis of novel biopolymers

合成肽疫苗是通过小生物活性基序聚合形成的，与传统方法相比，它具有若干优势，有望成为未来针对多种疾病的疫苗。疾病目标将包括流感和丙型肝炎病毒以及一种来自肠致病性大肠杆菌的毒素。这三种疾病迫切需要新的疫苗方法，而本提案中描述的化学物质代表了对传统的、迄今为止研究过的无效方法的概念飞跃。合成防冻蛋白和生物弹性体也将使用我们的催化驱动聚合工艺构建，并应用于未满足的医疗和工业需求。

Synthetic peptide-based vaccines, formed via polymerisation of small bioactive motifs, possess several advantages over traditional approaches and promise to be the multi-disease targeting vaccines of the future. Disease targets will include influenza and hepatitis C viruses and a toxin from enteropathogenic Escherichia coli. These three diseases are in desperate need of novel vaccine approaches and the chemistries described in this proposal represent a conceptual leap over traditional, and so far ineffective approaches investigated thus far. Synthetic antifreeze proteins and bioelastomers will also be constructed using our catalysis driven polymerisation process and applied to unmet medical and industrial needs.