Conference: Revisiting the Central Dogma of Molecular Biology at the Single-Molecule Level; July, 2019; Lima, Peru

该奖项将为研究生、博士后助理和职业生涯早期的独立科学家提供支持，以参加2019年7月18日至21日在秘鲁利马举行的国际会议。这次会议将汇聚单分子应用和纳米级可视化领域的领先者。这些方法揭示了DNA中编码的信息如何被读取和执行的分子细节。会议形式旨在促进初级和高级科学家之间的互动，因为在同一会议期间将举行主题讲座和简短演讲。圆桌讨论将包括新手和专家，以鼓励学生、博士后助理以及初级和高级教职员工之间的互动。会议将向潜在用户介绍这些技术的力量，促进跨学科合作。单分子操纵和可视化技术揭示了许多新的分子和细胞过程的操作原理，这些过程推动了信息从基因到蛋白质的流动，即分子生物学的中心教条。会议将涵盖单分子生物物理方法在DNA复制、转录、翻译和相关过程中取得的最新突破。在传播方面，组织者将在网站上向参与者和非参与者提供演讲摘要和海报。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The award will provide support for graduate students, post-doctoral associates and early career independent scientists to attend an international meeting in Lima, Peru July 18-21, 2019. The meeting will bring together leaders in the fields of single molecule applications and nanoscale visualization. These approaches reveal the molecular details of how the information encoded in DNA is read and implemented. The meeting format is designed to foster interactions between junior and senior scientists, as keynote lectures and short talks will be held in the same sessions. RoundTable discussions will mix novices and experts to encourage interactions among students, postdoctoral associates, and junior and senior faculty. The meeting will introduce the power of these techniques to potential users, fostering interdisciplinary collaborations. Single-molecule manipulation and visualization techniques have unveiled many new operating principles of the molecular and cellular processes that drive the flow of information from genes to proteins, i.e., the central dogma of molecular biology. The meeting will cover most of the recent breakthroughs produced by single molecule biophysical approaches in DNA replication, transcription, translation, and associated processes. In terms of dissemination, the organizers will make the abstracts of the talks and posters available to both participants and non-participants on a website.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.