STTR Phase I: Ambulatory, Beat-to-Beat Blood Pressure Tracking Enabled by Wireless, Tri-Mode Electronic Tattoos

这项小型企业技术转移（STTR）第一阶段项目的更广泛影响是解决高血压问题，高血压影响约7500万美国人，是美国每年近50万人死亡的主要或促成原因。高保真度和高可穿戴性血压（BP）追踪器将有助于高血压的诊断和控制。拟议的项目推进了“磨损即忘”电子纹身的设计和制造，这是一种可拉伸的混合电子设备，在纹身平台上集成了刚性和柔性组件，可作为未来软可穿戴电子产品的模型。除了改善高血压患者生活的社会影响外，无创的难以察觉的实时血压监测将有助于许多与人类健康和表现相关的领域，如健身训练、睡眠研究和前瞻性治疗治疗的临床试验。拟议的STTR第一期项目将开发一种机电声心脏（EMAC）纹身，用于连续和搏动血压（BP）跟踪。该项目将开发：1)运动伪影最小化的硬件和软件组合策略，这是任何动态生物识别传感长期寻求的；2)针对BP异常事件的个性化识别与预警的机器学习算法；3)综合系统解决方案。这些创新共同实现了首个具有高可穿戴性、低运动伪影和电子纹身可穿戴格式警告功能的动态、逐拍动态BP跟踪系统。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact of this Small Business Technology Transfer (STTR) Phase I project is to address hypertension, which affects about 75 million Americans and is the primary or contributing cause of nearly 500,000 deaths every year in the U.S. A high-fidelity and high wearability blood pressure (BP) tracker will help the diagnosis and control of hypertension. The proposed project Advance the design and manufacture of wear-and-forget e-tattoos, a stretchable hybrid electronic device integrating both rigid and soft components on a tattoo-like platform, serving as a model for future soft wearable electronics. In addition to the societal impact of improving the lives of hypertension patients, noninvasive imperceptible real-time BP monitoring would assist many fields related to human health and performance, such as fitness training, sleep studies, and clinical trials for prospective therapeutic treatments. The proposed STTR Phase I project will develop an electro-mechanical-acoustic cardiac (EMAC) tattoo for continuous and beat-to-beat blood pressure (BP) tracking. The project will develop: 1) A combined hardware and software strategy for motion artifact minimization, long sought for any ambulatory biometrics sensing; and 2) A machine learning algorithm for personalized recognition and warning of abnormal BP events; 3) An integrated systems solution. These innovations together enable the first ambulatory, beat-to-beat ambulatory BP tracking system with high wearability, low motion artifacts, and warning capabilities in an e-tattoo wearable format.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.