Supramolecular approaches for phase organization, particle formation, disintegration, and drug binding capacity in depsipeptide-based nanocarriers (A03)

该项目的目标是形成直径<100 nm的基于小寡缩肽（ODP）的纳米载体。通过采用ODP强稳定颗粒来定制药物装载和释放，从而通过形成致密基质来实现高药物包封和降低释放速率。将产生>100 nm的颗粒，其将被吸收到毛囊中，然后在暴露于外部刺激时根据需要分解成能够从毛囊渗透到周围真皮中的较小单元。应通过小尺寸纳米颗粒的形状记忆效应实现按需崩解的能力。

The formation of small oligodepsipeptides (ODP)-based nanocarriers with diameters <100 nm is the goal of this project. Drug loading and release will be tailored by employing ODPs strongly stabilizing particles, thereby enabling high drug encapsulation and lowering release rates by forming a dense matrix. Particles of >100 nm will be created, which will be taken up into hair follicles and will then disintegrate on demand upon exposure to an external stimulus into smaller units that are able to permeate from the hair follicle into the surrounding dermis. The capability to disintegrate on demand shall be implemented by a shape-memory effect of the small-sized nanoparticles.