CAREER: Ruthenium-Catalyzed Stereoselective and Site-selective Functionalization of Carbon-Hydrogen Bond

美国国家科学基金会（NSF）支持密西西比州立大学崔鑫教授的研究。本项目由美国国家科学基金会化学部化学催化项目和促进竞争性研究的既定计划（EPSCoR）共同资助。崔教授正在开发可用于药物和聚合物的有机化合物的新途径。具体的目标是发明一种方法，使有机化合物的行为与其镜像不同。这种类型的结构需要依赖于特别微妙的化学结构的方法。崔教授建议使用含有钌元素的催化剂来解决这些挑战。钌形成具有适当微妙结构的化合物，这有利于所需有机产品的形成。钌催化剂的系统变化将获得新的见解。该奖项还支持通过“学生对学生”的科学教育培训本科生和高中生。为参与的本科生提供动手实验室经验。崔教授组织的化学俱乐部为K-12学生提供STEM教育。总体而言，该研究项目有助于提高化学工业的可持续性和创新性，同时增加美国的技术劳动力。美国国家科学基金会（NSF）支持密西西比州立大学崔鑫教授的研究。本项目由美国国家科学基金会化学部化学催化项目和促进竞争性研究的既定计划（EPSCoR）共同资助。立体选择性碳氢化合物功能化因其在科学和经济上的巨大机遇而备受关注，但仍面临着重大挑战。崔教授正在迎接这一挑战，他的研究表明，钌（II）基催化剂对芳香C-H键的功能化非常有效。更令人感兴趣的是，他的研究揭示了新的立体选择性，特别是对映选择性，各种有机底物的功能化。这些发展开放了新药和相关生物活性化合物的获取。目标产品包括生物碱、手性聚合物和未来的手性配体。在一种方法中，正在开发手性定向基团以获得立体控制。在另一种方法中，一类新的手性伞状配体能够远距离立体控制碳氢官能化反应。总的来说，这两个主题提供了新的基本见解，将增强合成方法，以及展示钌（II）催化的未开发潜力。在实验室研究的同时，崔教授还带领着一个本科生团队，旨在让年轻一代熟悉现代有机化学。他的团队还旨在鼓励高中生和本科生的参与。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The National Science Foundation (NSF) supports the research of Professor Xin Cui at Mississippi State University. This project is jointly funded by Chemical Catalysis Program of NSF's Division of Chemistry and the Established Program to Stimulate Competitive Research (EPSCoR). Professor Cui is developing new routes to organic compounds that could be used in drugs and polymers. The specific goal is the invention of ways to make organic compounds that are behave differently from their mirror images. This type of structure requires methods that rely on particularly subtle chemical structures. Professor Cui proposes to solve these challenges using catalysts containing the element called ruthenium. Ruthenium forms compounds with appropriately subtle structures, which facilitate the formation of desired organic products . New insights will be obtained by systematic changes in the ruthenium catalysts. The award also supports the training of undergraduate and high school students through “student-to-student” science education. Hands-on laboratory experience is provided to participating undergraduates. The chemistry club organized by Professor Cui provide STEM education to K-12 students. Overall, this research project helps to improve the sustainability and innovation of the chemical industry while increasing the technical workforce of the United States.The National Science Foundation (NSF) supports the research of Professor Xin Cui at Mississippi State University. This project is jointly funded by Chemical Catalysis Program of NSF's Division of Chemistry and the Established Program to Stimulate Competitive Research (EPSCoR). Stereoselective C–H functionalization has attracted much attention because the opportunities are significant both scientifically and economically, but still faces major challenges. This challenge is being met by Professor Cui whose research shows that ruthenium(II)-based catalysts are highly effective for functionalization of aromatic C–H bonds. Of still greater interest, his research reveals new stereoselective, particularly enantioselective, functionalization of various organic substrates. These developments open access to new pharmaceuticals and related bioactive compounds. Products targeted include alkaloids, chiral polymers, and future chiral ligands. In one approach, chiral directing groups are being developed for conferring stereocontrol. In another approach, a new class of chiral umbrella-shaped ligands enable long-range stereocontrol of C‒H functionalization reactions. Overall, the two themes are providing new fundamental insights that will enhance synthetic methods as well as to demonstrate the untapped potential of ruthenium(II)-catalysis. In parallel with the laboratory research, Professor Cui leads an undergraduate team that aims to familiarize young generations with modern organic chemistry. His team also aims to encourage the participation of high school and undergraduate students.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.