Ferrocene-based Chiral Intramolecular Frustrated Lewis Pairs

该研究项目涉及1，2-二茂铁基配体轴承空间阻碍刘易斯酸和庞大的刘易斯碱的适当设计。这项工作的目标是产生具有平面和中心手性的刘易斯对，并且能够：i）异裂二氢裂解，得到两性离子物质[LAH]-[LBH]+（LA =刘易斯酸，LB =刘易斯碱），其可以进一步将两个氢原子作为质子和氢化物转移，使该刘易斯对用作有机底物的不对称氢化的催化剂和用作氢化物转移催化剂; ii）R3 E-H的活化（E = C，Si）键，允许刘易斯对应用于例如催化不对称氢化硅烷化和C-H硼基化反应; iii）作为两亲性配体通过M-与过渡金属进行配位电子背键相互作用，可以在催化交叉偶联反应中发挥至关重要的作用;（iii）活化和固定的小分子，如CO2，N2 O，P4，烯烃，二烯烃和炔烃，这将提供激动人心的可能性，探索新的反应途径。

The research project deals with the appropriate design of 1,2-ferrocenyl ligands bearing sterically encumbered Lewis acids and bulky Lewis bases. The goal of the work is to generate Lewis pairs featuring planar and central chirality and that are capable of: i) heterolytic dihydrogen cleavage to give the zwitterionic species [LAH]-[LBH]+ (LA = Lewis acid, LB = Lewis base), which can further transfer the two hydrogen atoms as a proton and an hydride, allowing the Lewis pair to be used as catalyst for the asymmetric hydrogenation of organic substrates and as hydride transfer catalyst; ii) activation of R3E-H (E = C, Si) bonds permitting application of the Lewis pair for example in catalytic asymmetric hydrosilylation and C-H borylation reactions;iii) behavior as ambiphilic ligand for the cooperative coordination of transition metals through M-E back bonding interactions that can plays a vital role in catalytic cross coupling reactions;(iii) activation and fixation of small molecules such as CO2, N2O, P4, alkenes, dienes and alkynes, which will provide thrilling possibilities to explore new reaction pathways.