Percutaneous laser-assisted resection of the aortic valve

最近，心脏瓣膜安装金属支架（带瓣支架）可以通过创新的经导管技术（即经顶部或经股动脉）植入狭窄主动脉瓣的位置。为了避免这些导管介入手术期间的并发症，必须在手术前切除病变的自体瓣膜。为了实现这一目标，基尔校区大学医院心血管外科将进一步开发和扩展第一个资助期内制定的手术器械和手术技术。同时，在吕贝克大学生物医学光学研究所，用于微创切割心脏瓣膜的激光系统的脉冲能量将进一步提高。这将实现对钙化和非钙化心脏瓣膜组织的最佳切割效率。所开发的仪器将在体内猪模型和死后人体模型的合作实验中进行优化。此外，激光-组织相互作用的组织学研究将完成拟议的项目。

Recently, heart valve mounted metal scaffolds (valved stents) can be implanted in the position of a stenotic aortic valve via innovative transcatheter technics, i.e. transapically or transfemorally. In order to avoid complications during those catheter interventions, the diseased native valve has to be resected before.To achieve this, the operative instruments as well as the surgical technique elaborated during the first funding period will be further developed and expanded at the Department of Cardiovascular Surgery, University Hospital, Campus Kiel.In parallel, at the Institute for Biomedical Optics of the University Lübeck the pulse energies of the laser system for minimally invasive cutting of heart valves will be further enhanced. This will realize a best possible cutting efficiency for calcified as well as non-calcified heart valve tissue.The developed instrumentation will be optimized in cooperate experiments on an in vivo porcine model and a post mortem human model. Furthermore, histological investigations of laser-tissue interactions will complete the proposed project.