Emerging Roles for the Nucleolus - American Society for Biochemistry and Molecular Biology Symposium

该项目的首要目标是促进下一代研究人员的出席、教育、参与和融入核仁生物学。会议由美国生物化学与分子生物学学会（ASBMB）组织。2017年首次举办，2019年将举行第二次。该系列会议填补了生物学会议的空白，因为它是近10年来唯一一个专门讨论核仁生物学的会议。会议将向早期职业科学家介绍一系列领导者和观点，并允许早期职业科学家分享他们的观点，帮助他们成为未来的领导者。会议的规模和设置促进了科学的讨论和合作，合作是一个结果。从那些研究生物物理特性的科学家到那些试图了解模式生物基本功能的科学家，再到那些针对其在癌症和罕见发育综合征中的活性的科学家，核核是一种通常不聚集的广泛科学家感兴趣的核细胞器。在这次会议上，所有这些人都团结在一个屋檐下，以促进沟通。任何领域要蓬勃发展，都必须支持不同的观点，培养下一代领导者，这也是本提案的主要目标。这次跨学科会议将集中讨论与核仁生物学有关的一系列主题。这些包括核糖体DNA序列的稳定性和多样性、核仁的生物物理特性、成像方法的新进展以及核仁在健康、应激和疾病中的功能。该项目旨在促进互动和讨论，包括海报会议和共享餐，其中包括“专家见面会”午餐，在午餐中，高级领导人与一群早期职业科学家坐在一起，就科学和职业相关话题进行非正式交谈。除了10位受邀演讲者外，还选择了24篇摘要作为平台演讲，其中14篇来自早期职业科学家，主要是博士后和研究生。组织者在包容性和多样性方面做出了重大努力。会议的组织框架包括一个由资深和早期职业科学家作为共同组织者和会议主席的团队。本次大会男女演讲者的比例大致相等，所有平台演讲的要求都得到了满足。为了促进国际讨论，该项目包括来自9个国家的演讲者。演讲者可以选择写一篇评论文章发表在《生化学会汇刊》上。为了提高公众的科学意识，2019年的会议推出了一项STEAM倡议，其中核仁的艺术图像将被组装成一个艺术页面，并制作成横幅。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The overarching objective of the project is to facilitate the attendance, education, participation, and integration of the next generation of researchers into nucleolar biology. The conference is organized by the American Society of Biochemistry and Molecular Biology (ASBMB). It was held for the first time in 2017 and will be held for the second time in 2019. This conference series fills a gap in biology meetings because it is the only conference devoted to nucleolar biology in the last 10 years. The conference will introduce early career scientists to an array of leaders and perspectives and will allow early career scientists to share their perspectives, helping them to become the leaders of the future. The meeting size and setting fosters scientific discussion and collegiality, with collaborations emerging as one outcome. The nucleolus is a nuclear organelle of interest to a wide array of scientists who do not normally convene, from those studying the biophysical properties to those trying to understand basic functions in model organisms, to those targeting its activity in cancer and rare developmental syndromes. All of these individuals are united under one roof at this meeting to foster communication. For any field to flourish, it is imperative to support diverse perspectives and build the next generation of leaders, which is the main objective of this proposal.This interdisciplinary conference will focus on a range of topics related to nucleolar biology. These include the stability and diversity of ribosomal DNA sequences, the biophysical properties of the nucleolus, new advances in imaging methods, and the function of the nucleolus in health, stress and disease. The program is designed to facilitate interactions and discussions, with a poster session and shared meals, including a "meet the experts" lunch in which senior leaders are seated with a group of early career scientists for informal conversation about science and career related topics. In addition to ten invited speakers, twenty-four abstracts were chosen for platform presentations of which fourteen are from early career scientists, primarily postdocs, and graduate students. Significant efforts have been made by the organizers for inclusion and diversity. The meeting's organizational framework includes a team of both a senior and early career scientist as co-organizers and session chairs. The conference has a roughly equal split between male and female speakers, and all requests for a platform presentation were accommodated. Promoting international discussions, the program includes speakers from nine countries. Speakers will have the option to write a review article for publication in Biochemical Society Transactions. To promote scientific awareness with the public, the 2019 meeting boasts a STEAM initiative, in which artistic images of nucleoli will be assembled into an art page and made into a banner.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.