Catalytic Alkene Carbofunctionalization and Carbodifunctionalization: Catalyst Identification, Reaction Development, and Mechanistic Insights

美国国家科学基金会化学部的化学合成项目通过该奖项支持爱荷华州立大学李维·斯坦利博士的研究，以开发对有机合成领域有用的新化学反应。具体来说，在这项研究中，研究小组正在开发化学反应，将简单且容易获得的化学构建块结合起来，形成具有更大复杂性和理想特性的新化合物或酮类。正在发展的化学增加了有机和药物化学家用于研究生物系统和开发治疗剂的方法的稳定性。特别是，该团队寻求开发化学催化剂，以高效调解目标化学转化；这是这个研究项目的核心。该研究为培养本科生和研究生解决重大科学挑战提供了一个平台。这些研究的性质使学生能够获得化学多个领域的技能，并为学生的职业生涯做好准备，这些职业需要解决越来越多的跨学科问题的能力。预计将从计划中的教育活动中获得额外的社会效益，以提高STEM学科的保留率，并从爱荷华州K-12学生和公众的新STEM推广活动中获得额外的社会效益。李维·斯坦利和他的学生们正在开发新的化学反应和催化剂，用于目标转化，以产生对药物、工艺和材料化学家很重要的羰基化合物。这些反应将容易得到的烯烃和炔烃、羧酸衍生物和有机金属亲核试剂偶联，形成新的羰基化合物。这些研究是由一个中心假设驱动的，即由过渡金属催化剂活化羧酸衍生物产生的化学中间体可以用来开发一系列新的烯烃和炔功能化反应。新的烯烃和炔功能化反应简化了羰基化合物的合成，并通过形成碳-碳键的新方法提供了多种有价值的分子结构。这项工作的进一步广泛影响包括对学生进行现代合成化学和催化科学方面的培训，通过让本科生参与实验室研究经验来增加STEM保留率，以及重要的STEM推广活动。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With this Award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Dr. Levi Stanley of Iowa State University to develop new chemical reactions that are useful for the field of organic synthesis. Specifically, in this study, the research team is developing chemical reactions that combine simple and readily available chemical building blocks to form new compounds or the ketone class with greater complexity and desirable characteristics. The chemistry being developed adds to the stable of methodology utilized by organic and medicinal chemists to study biological systems and develop therapeutic agents. In particular, the team seeks to develop chemical catalysts that mediate the targeted chemical transformations with high efficiency; this is central to this research program. The research provides a platform for training undergraduate and graduate students to solve important scientific challenges. The nature of the studies enables students to gain skills in multiple areas of chemistry and prepares students for careers that require the ability to solve increasingly interdisciplinary problems. Additional societal benefits are expected to accrue from the planned educational activities to increase retention in STEM disciplines and from new STEM outreach activities for K-12 students and the public in Iowa.Dr. Levi Stanley and his students are developing new chemical reactions and catalysts for the targeted transformations to generate carbonyl compounds that are important to medicinal, process, and materials chemists. The reactions couple readily accessible alkenes and alkynes, carboxylic acid derivatives, and organometallic nucleophiles to form new carbonyl compounds. The studies are driven by a central hypothesis that chemical intermediates generated by activation of carboxylic acid derivatives with a transition metal catalyst can be harnessed to develop a range of new alkene and alkyne functionalization reactions. The new alkene and alkyne functionalization reactions streamline syntheses of carbonyl compounds and provide access to a variety of valuable molecular architectures via new methods to form carbon-carbon bonds. Further broader impacts of this work include training for students in modern synthetic chemistry and catalysis science, increasing STEM retention by engaging undergraduate students in laboratory research experiences, and significant STEM outreach activities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.