SBIR Phase I: Hemorrhagic Stroke Detection with Electrochemical Impedance Spectroscopy ;

这个小型企业创新研究(SBIR)第一阶段项目的更广泛影响/商业潜力是研究一种负担得起的出血性中风(HS)检测设备。目前最先进的院前HS检测技术是计算机断层成像救护车(即移动卒中单元)。移动中风设备的前期成本和运营成本都很高，而一种成本较低的设备可能会在两个方面彻底改变中风患者的医疗保健。首先，院前识别使这些患者能够被分流到配备有治疗他们的医院(神经外科中心)，从而获得更快的护理和更好的结果。其次，院前排除HS的能力将允许更早地治疗另一种疾病--缺血性中风，以改善结果并降低长期医疗成本。拟议的SBIR第一阶段项目将使用电化学阻抗谱(EIS)来区分HS和缺血性中风。EIS包括注入交流信号并测量频率谱上产生的阻抗。材料的阻抗谱往往不同，这使得EIS在各种应用中都很有用，包括腐蚀检查、抗体结合、身体成分和疾病诊断。这项工作将推进EIS的使用，到目前为止，EIS还在实验中用于检测颅内病理，以检测大脑中的出血组织。这项工作将探索快速获取EIS HS检测设备的开发。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to investigate an affordable prehospital hemorrhagic stroke (HS) detection device. The current state-of-the-art technology for prehospital HS detection is a computed tomography ambulance (i.e. mobile stroke unit). Mobile stroke units have high upfront and operating costs, and a lower-cost device could revolutionize healthcare for stroke patients in two ways. First, prehospital identification allows these patients to be triaged to hospitals equipped to treat them (neurosurgical centers), resulting in faster care and better outcomes. Second, the ability to rule out HS prehospital will allow earlier treatment of another condition, ischemic stroke, to improve outcomes and reduce long-term healthcare costs. The proposed SBIR Phase I project will use electrochemical impedance spectroscopy (EIS) to differentiate HS and ischemic stroke. EIS involves injecting an alternating current signal and measuring the resulting impedance across a spectrum of frequencies. The impedance spectrum of materials often differ, allowing EIS to be useful in a variety of applications including examination of corrosion, antibody binding, body composition, and disease diagnosis. This work will advance the use of EIS, to date used experimentally in detecting intracranial pathologies, to detect hemorrhagic tissue within the brain. This work will explore the development of a fast-acquisition EIS HS detection device.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.