MRI: Acquisition of a solid/liquid-state 700 MHz NMR instrument for the Southeast

路易斯安那州立大学（LSU）获得了一项奖励，以支持购买具有固态和液态功能的700 MHz核磁共振（NMR）光谱仪。该仪器为路易斯安那州提供了高场NMR能力，以支持各种生物分子项目，提高研究和学生培训的质量，并在东南部建立区域高场NMR设施。该组织间工具将立即为来自5个路易斯安那州立大学校园和7个区域机构的23个研究项目提供服务，汇集了189名博士后，研究生和本科生研究人员。该用户群包括85名女性研究人员，21名非裔美国学生和11名其他少数民族用户。一个全面的计划（包括用户培训和开放式活动，NMR课程，本科生研究和推广计划，以及研讨会和会议）将招募新用户，并促进NMR光谱学，化学和结构生物学，微生物学，植物生物学和生物材料研究的培训。新仪器提供了一个显着的改善基础设施的磁场强度比现有设施的1.4-1.8倍增强。分辨率和灵敏度的巨大提高具有巨大的潜力，可以推动不同研究领域的知识发展。此次收购所支持的项目包括（i）蛋白质-膜相互作用，（ii）蛋白质-蛋白质和蛋白质-配体复合物的研究，这些复合物将揭示与一系列生理过程相关的生化过程，（iii）野生型和转基因植物和真菌中的碳水化合物结构，以及（iv）仿生材料。该仪器将鼓励并使具有不同水平NMR专业知识的用户能够将NMR作为其研究项目中的一个有价值的组成部分。仪器上收集的数据将用于课程设置，并在同行评审的期刊和科学会议上传播。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to Louisiana State University (LSU) to support the acquisition of a 700 MHz nuclear magnetic resonance (NMR) spectrometer with both solid- and liquid-state capabilities. The instrument provides Louisiana with high-field NMR capability to enable a variety of biomolecular projects, improve the quality of research and student training, and establish a regional high-field NMR facility in the Southeast. The inter-organizational instrument will immediately serve 23 research programs from 5 LSU campuses and 7 regional institutions, bringing together 189 postdoctoral, graduate, and undergraduate researchers. This user base includes 85 female researchers, 21 African American students, and 11 users from other minorities. A comprehensive program (including user-training and open-house events, NMR courses, undergraduate research and outreach programs, and seminars and conferences) will recruit new users and facilitate training in NMR spectroscopy, chemical and structural biology, microbiology, plant biology, and biomaterial research. The new instrument affords a significant improvement of infrastructure by a 1.4–1.8-fold enhancement of magnetic field strengths over the existing facility. The tremendous increase in resolution and sensitivity has immense potential to advance knowledge across diverse research fields. The projects enabled by the acquisition include studies of (i) protein-membrane interactions, (ii) protein-protein and protein-ligand complexes that will reveal the biochemical processes associated with a range of physiologic processes, (iii) carbohydrate structures in wild-type and transgenic plants and fungi, and (iv) biomimetic materials. The instrument will encourage and enable users with varying levels of NMR expertise to embrace NMR as a valuable component in their research projects. The data collected on the instrument will be used in course offerings and disseminated in peer-reviewed journals and at scientific meetings.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.