I-Corps: Laparoscopic Induction Heaters for Biomedical Applications

这个I-Corps项目的更广泛的影响/商业潜力是微型感应加热器的发展，以加热人体内难以触及的地方的导电材料。目标是开发更小，更集中的磁场应用器，可用于有金属植入物（例如，髋关节置换术植入物，支架等）的患者，否则无法接受目前基于磁性纳米颗粒的癌症治疗。此外，其目的是开发新的医疗程序，需要在人体相对难以接近的部位对导电材料进行原位非接触式加热。这个I-Corps项目是探索微型感应加热设备在生物医学应用中的翻译，例如在腹腔镜手术中，目的是使用磁流体热疗（MFH）治疗腹膜内转移性癌症，如卵巢癌。其功能包括在290kHz频率下产生高达18 kA/m的交变磁场。在这种场强下，根据颗粒浓度的不同，可以将不锈钢盘加热到500°C以上，将氧化铁磁性纳米颗粒悬浮液加热到39°C至96°C的最高温度。转化研究包括：a)开发新的磁场发生器，允许更局部的MFH前列腺癌治疗，b)进一步探索微型感应加热器的概念，以加热人体难以触及的部位的导电材料。C)确定该技术在体外加热磁性纳米颗粒杀死癌细胞的能力，d)确定该设备在加热磁性纳米颗粒烧蚀猪组织的能力，并估计不同操作条件下组织损伤的严重程度和程度。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is the development of miniature induction heaters to heat electrically conductive materials in hard-to-reach places within the human body. The goal is to develop smaller, more focused magnetic field applicators that may be used in patients having metallic implants (e.g., hip replacement implants, stents, etc.) otherwise ineligible to receive current magnetic nanoparticle-based cancer therapies. Additionally, the aim is to enable the development of new medical procedures requiring in situ, non-contact heating of electrically conductive materials in relatively inaccessible places within the human body. This I-Corps project is to explore translation of miniature induction-heating devices for biomedical applications, such as in laparoscopic procedures with the intention of treating intra-peritoneal metastatic cancer such as ovarian cancer using magnetic fluid hyperthermia (MFH). Capabilities include generating an alternating magnetic field of up to 18 kA/m at a frequency of 290kHz. With this field intensity, it is possible to heat a stainless-steel disk to more than 500°C and a suspension of iron oxide magnetic nanoparticles to maximum temperatures ranging from 39°C to 96°C, depending on particle concentration. Translational research includes: a) development of novel magnetic field generators allowing a more localized MFH prostate cancer therapy, b) further exploration of the concept of having miniature induction heaters to heat electrically conductive materials in hard-to-reach places within the human body, c) determining the capabilities of the technology in heating magnetic nanoparticles to kill cancer cells in vitro and d) determining the devices' capabilities in heating magnetic nanoparticles to ablate porcine tissues and estimate severity and extent of tissue damage under different operating conditions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.