STTR Phase I: A Pair of Linked Cartographic Maps of our Brain Derived from Clinical Glaucoma Data

这个小型企业技术转让(STTR)第一阶段项目的更广泛的商业潜力是改善眼睛保健的可及性。青光眼是不可逆性失明的一个主要原因，但可以通过早期发现加以解决，而且患病率随着年龄的增长而增加。然而，现有的测试可能会很累和困难，并且需要专门的设备。该项目将推进一种廉价的检测，以便及早发现并治疗。这种低成本、基于平板电脑的工具可以提供普遍、经济高效的青光眼筛查。这项小型企业技术转移(STTR)第一阶段项目通过改进视觉系统的建模和数据分析，推动了用于青光眼检测的新型视网膜测试的发展。该项目分析视野测试结果，以揭示一对链接的地图，这些地图通过在保角映射中分离的分组视网膜神经纤维束将中央和外围视网膜信息传输到大脑。中心凹中心轴为中心的S2球状非欧氏黎曼面，在大脑中缺乏代表性，可视为每只眼睛的奇点或参照区。S2表面的信息通过视网膜神经纤维束传输，这些神经纤维束被分组表示单个表面，并将眼睛建模为S3 4维超球体，盲点是奇点区域并用作参考点。将信息传递给大脑的视网膜神经纤维束在盲点被被动地重新排序，并导致Y轴(上下)的反转。来自两只眼睛的信息能够消除视差，并导致深度感知。来自每只眼睛周边视网膜区域的信息穿过视交叉，并在周边视觉期间提供物体的空间位置。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to improve the accessibility of eye health care. Glaucoma is a major cause of irreversible blindness but can be addressed with early detection, and the prevalence increases with age. However, existing tests can be tiring and difficult and require specialized equipment. This project will advance an inexpensive test for early detection for treatment. This low-cost, tablet-based tool can offer universal, cost-effective glaucoma screening.This Small Business Technology Transfer (STTR) Phase I project advances novel retinal testing for glaucoma detection through improved modeling and data analysis of the visual system. This project analyzes visual field test results to reveal a pair of linked cartographic maps that transmit central and peripheral retinal information to the brain through grouped retinal nerve fiber bundles segregated in a conformal mapping. A cone of photons displays the visual field information on the central S2 spherical non-Euclidean Riemann surface centered around the foveal axis, which lacks representation in the brain and can be considered as a singularity or reference region for each eye. Information on the S2 surface is transmitted through bundles of retinal nerve fibers that are grouped to represent single surfaces, and modeled as though the eye is a S3 4-dimensional hypersphere, with the blind spot being a singularity region and serving as the reference point. The retinal nerve fiber bundles transmitting the information to the brain are passively reordered at the blind spot and bring about an inversion of the Y (Up-Down) axis. Information from both eyes enables parallax removal and leads to depth perception. Information from the peripheral retinal regions of each eye is crossed across the optic chiasma and provides spatial locations of objects during peripheral vision.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.