SBIR Phase I: HaloFilm as a virucide against COVID-19 infection

这项小企业创新研究（SBIR）第一阶段项目的广泛影响是开发一种具有独特应用和功效特征的抗病毒表面涂层。有证据表明，COVID-19病毒株可以在不锈钢和塑料上存活长达三天，这在地铁转门、公共汽车和医院高接触表面等高流量环境中可能是有害的。此外，即使在医院，清洁和消毒也可能不够全面，表面可能很容易被再次污染，直到重新使用消毒剂。拟议的技术使含氯消毒剂的有效期长达4周。该涂层使氯保持在物理和化学状态，对病毒有活性，但仍然安全，接触时不会引起皮肤刺激。这种涂层可以将任何表面变成抗菌和抗病毒的表面。拟议的SBIR第一期项目将评估一种可充电且可重复使用的喷涂表面涂层的效用、有效性和安全性，使其可以用作抗菌表面涂层，特别是用于防止冠状病毒的传播。最先进的是定期使用液体喷雾消毒剂杀死表面上的病毒。然而，典型的活性成分，如氯、季铵化合物、酒精、过氧乙酸或过氧化氢，对病毒的活性只有几分钟，肯定不到一个小时，留下的表面可能会被重新污染。该提案的技术目标集中在1)评估涂层在应用后特定时间的病毒活性；2)测定冠状病毒在涂层上的半衰期，以便与其他材料进行比较。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact of this Small Business Innovation Research (SBIR) Phase I project is to develop an antiviral surface coating with unique application and efficacy features. Evidence suggests that the COVID-19 virus strain can remain live on stainless steel and plastic for as long as three days, a potentially harmful situation in environments with high traffic, such as subway turnstiles, buses, and high-touch surfaces in hospitals. Furthermore, even in hospitals, cleaning and disinfecting can be insufficiently comprehensive than desired, with surfaces that may easily be recontaminated until disinfectants are reapplied. The proposed technology enables chlorine-based disinfectants to be effective for as long as 4 weeks. The coating keeps chlorine in a physical and chemical state that is active against viruses, but remains safe and does not cause skin irritation upon contact. The coating can turn any surface into an antimicrobial, and antiviral, surface. The proposed SBIR Phase I project will assess the utility, efficacy and safety of a spray-on surface coating that is rechargeable and can be reapplied, such that it can be used as an antimicrobial surface coating, particularly to prevent transmission of coronaviruses. The state-of-the-art is to regularly use liquid spray disinfectants to kill viruses on surfaces. However, typical active ingredients, such as chlorine, quaternary ammonium compounds, alcohol, peracetic acid or hydrogen peroxide, are active against viruses for a matter of minutes and certainly less than an hour, leaving a surface that can potentially be recontaminated. The technical aims of the proposal focus on 1) assessing the virucidal activities of the coating at specific times after application; 2) determining the half-life of coronaviruses on the coating for comparison to other materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.