SBIR Phase I: Photoactivated coatings & cleaners to disable COVID-19 on hospital high touch surfaces

这个小企业创新研究第一阶段项目的更广泛的影响/商业潜力是开发新的工具来减少SARS-CoV-2病毒的传播和相关的新冠肺炎大流行。该项目开发的材料平台将有助于控制和防止病毒、细菌和其他可能导致大流行的病原体的表面传播。该项目将推进一种坚固的涂层，可以在使用点应用，以减少新冠肺炎的面对面传播。这项技术可能有助于减少患者和护理人员之间的感染传播。这个SBIR第一阶段项目建议开发耐用和无毒的杀毒涂料，该涂料包含可见光刺激的光催化材料和在坚固的聚合物基质中的黑暗活性材料。持续的抗致病作用是在房间里的灯光下激活的；黑暗的活性物质在日常清洁之间提供消毒物种。这种涂层将使SARS-CoV-2等病毒以及其他细菌和细菌孢子失效。这些目标克服了当前抗菌涂层技术的主要缺陷，这些缺陷限制了其应用，包括使用紫外线(UV)、聚合物涂层随时间降解以及涂层在弱光条件下的毒性和无效。这项拟议的研究将开发一种无毒涂层，通过改进光催化剂和涂层，增强其在弱光环境中的性能，并利用涂层与常用液体消毒剂之间的化学协同作用，在白光下提供更高的杀灭病毒活性。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the development of new tools to reduce transmission of SARS-CoV-2 virus and the associated COVID-19 pandemic. The materials platform developed in this project will help control and prevent surface-borne transmission of viruses, bacteria, and other pathogens with the potential to cause pandemics. The project will advance a robust coating that can be applied at point-of-use to reduce the hand-to-face spread of COVID-19. This technology may help reduce infection transmission among patients and care providers. This SBIR Phase I project proposes to develop durable and non-toxic virucidal coatings containing visible-light-stimulated photocatalytic materials and a dark active material in a robust polymer matrix. The continuous antipathogenic action is activated with room light; the dark active material provides disinfecting species between daily cleanings. The coating will disable viruses, such as SARS-CoV-2, as well as other bacteria and bacterial spores. These objectives overcome key drawbacks of current antimicrobial coating technology that limit its application, including the use of ultraviolet light (UV), degradation of polymeric coatings with time, and toxicity and ineffectiveness of the coatings in low-lighting conditions. The proposed research will develop a non-toxic coating offering improved viricidal activity with white light, by modifying the photocatalyst and coating, enhancing the performance in low-light environments, and exploiting chemical synergistic interactions between the coating and commonly used liquid disinfectants.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.