The interplay between hedonic and hormonal stimuli in the central regulation of energy and glucose metabolism in humans (B02)

该项目将描述享乐-情绪和激素刺激在调节人类体重方面的葡萄糖和能量稳态中的相互作用。在第一个资助期，我们的数据揭示了视觉食物线索对男性葡萄糖代谢的影响，以及催产素的厌食和血糖调节潜力。在第二个资助期，我们将进一步研究享乐刺激范式（视觉食物线索，“在公司吃饭”）对男性葡萄糖代谢和食物摄入的影响，以及鼻内催产素对瘦和肥胖女性这些参数的影响，以发现性别差异。基于在动物实验中有希望的结果，我们还将研究加压素对人类食物摄入的影响。通过结合“在公司吃饭”和鼻内催产素，我们旨在描述刺激享乐成分和厌食激素成分对人类食物摄入的影响。我们的研究结果将有助于产生由奖励处理功能障碍和能量密集食物过剩引起的肥胖的治疗策略。

This project will characterize the interplay of hedonic-emotional and hormonal stimuli in the regulation of glucose and energy homeostasis in humans with respect to body weight. In the first funding period, our data revealed the impact of visual food cues on glucose metabolism as well as the anorectic and glucoregulatory potential of oxytocin in men. In the second funding period, we will closer investigate the impact of hedonic stimulatory paradigms (visual food cues, "eating in Company") on glucose metabolism and food intake in men as well as the impact of intranasal oxytocin on these parameters in lean and obese women to detect gender differences. Based on promising results in animals, we will also investigate the impact of vasopressin on food intake in humans. By combining “eating in company” and intranasal oxytocin, we aim at characterizing the impact of the stimulatory hedonic component and the anorectic hormonal component on food intake in humans. Our results will help to generate treatment strategies for obesity caused by dysfunction in reward-processing and by the surplus of energy-dense foods.