I-Corps: A Hybrid Photo-Magnetic Field Generator for Assessment of Nanoscale Materials and Therapeutic Molecules

这个I-Corps项目的更广泛的影响/商业潜力是开发一种新型装置，用于同时对目标进行光学和振荡磁场照射。该装置在基础研究、转化研究、临床研究以及生物医学和制药工业应用的广泛领域具有潜在的应用前景，涉及下一代小分子药物和生物制剂的独特纳米平台表征和疗效评估，从而开发新的治疗方法。该项目的成功将使先进的治疗方法能够诱导最终的联合肿瘤细胞破坏。这个I-Corps项目推进了光磁混合场产生装置的翻译，用于同时对目标进行光学和振荡磁场照射，以解决光热、磁热和光动力激活的协同效应。利用这种装置，一种被称为“混合光磁刺激”的多模式综合策略在各种材料和生物系统中得以实现，这种策略以前从未被探索过。该装置允许同时光学和（低/高频）交流磁场暴露，从而根据目标的成分和特性产生累积或协同效应。这项新技术允许在照射过程中使用较弱的交流磁场与光刺激相结合，从而消除了与交流磁场辅助疗法相关的安全问题。利用该装置，观察到基于智能纳米结构的光磁混合照射是一种可行的远程指导肿瘤细胞破坏的方法，可用于临床管理治疗侵袭性癌症。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is the development of a novel device for simultaneous optical and oscillating magnetic field irradiation of a target. This device has potential applications in broad areas of basic, translational, and clinical research as well as biomedical and pharmaceutical industrial applications, which involve the unique nanoplatform characterization and efficacy assessment of next generation small molecule drugs and biologics toward the development of novel therapeutic approaches. The success of this project will enable advanced therapies to induce ultimate combined tumor cell destruction. This I-Corps project advances translation of a photo-magnetic hybrid field-generating device for simultaneous optical and oscillating magnetic field irradiation of a target to address the synergistic effects of photothermal, magnetothermal, and photodynamic activations. Using this device, a multimodal comprehensive strategy called “hybrid photo-magnetic stimulation” that has been unexplored previously is implemented with various materials and biological systems. This device permits simultaneous optical and (low/high frequency) AC magnetic field exposure, and thereby generates cumulative or synergetic effects depending on the target’s composition and characteristics. This novel technology permits the use of a less intense AC magnetic field in combination with optical stimulation during the irradiation process, thus removing the safety concerns associated with the AC magnetic field-assisted therapies. Using this device, it has been observed that smart nanostructure-based photo-magnetic hybrid irradiation is a viable approach to remotely guide tumor cell destruction, which may be adopted in clinical management to treat aggressive cancers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.