CAREER: Designing Hypervalent Bismuth Complexes with Reactive Perfluorinated Groups for Selective Organofluorination and Expanding Outreach in STEM Education in Hawaii.

在化学系化学合成项目的支持下，夏威夷大学马诺阿分校化学系的Jakub Hyvl博士正在研究铋化合物的合成，这种化合物有可能被开发成昂贵金属的替代品，目前用于促进重要的化学转化。许多化学反应需要催化剂以可接受的速率进行。一类重要催化剂的共同特征是它们获得和失去电子的能力；即参与氧化或还原过程。由于许多这些催化剂含有昂贵的金属，如铂，人们对发现基于较便宜成分的类似催化剂非常感兴趣。在这个项目中，正在探索铋化合物的制备，这种化合物具有铂特有的电子增益/损失。该项目专注于铋，因为它比铂便宜得多，对环境也更无害。除了科学项目，还有一个教育组成部分，包括与当地项目和科学教师的密切合作。它将吸引初高中学生，尤其是夏威夷原住民，以及其他未被充分代表的学生。铋价格低廉，储量丰富，而且无毒。本项目旨在合成具有贵金属过渡金属配合物反应活性的铋化合物。在该项目的研究部分，正在合成能够进行有效的二氟化和全氟烷基化反应的有机铋种类。这些涉及具有扩展配位数的高价铋化合物，可以在氧化态Bi(III)/Bi(V)和Bi(I)/Bi（III）之间循环。这些属性将用于促进选择性有机氟转移，这是一种具有挑战性的药学相关转化。该项目的教育部分将涉及K-12学生，与当地项目和科学教师合作，并重点关注夏威夷原住民和其他传统上未被充分代表的少数民族。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With the support of the Chemical Synthesis Program of the Division of Chemistry, Dr. Jakub Hyvl of the University of Hawaii–Manoa, Department of Chemistry, is studying the synthesis of bismuth compounds, which potentially can be developed into replacements for expensive metals that currently are used to facilitate important chemical transformations. Many chemical reactions require catalysts to proceed at and acceptable rate. A common characteristic of one important type of catalysts is their ability to gain and lose electrons; that is to participate in oxidative or reductive processes. Since many of these catalysts contain expensive metals such as platinum, there is great interest in discovering similar catalysts based on less expensive components. In this project, the preparation of bismuth compounds that are capable of the sort of gain/loss of electrons typical of platinum is being explored. The project focuses on bismuth because it is much cheaper and environmentally more benign than platinum. In addition to the scientific project, there is an educational component that involves close collaborations with local programs and science teachers. It will engage middle and high school students, especially Native Hawaiian, and other underrepresented students.Bismuth is inexpensive, abundant, and non-toxic. This project aims at synthesizing bismuth compounds that mimic the reactivity of noble metal transition metal complexes. In the research portion of this project, organobismuth species that are capable of performing efficient difluorocarbenation and perfluoroalkylation reactions are being synthesized. These involve hypervalent bismuth compounds with an expanded coordination number that can cycle between oxidation states Bi(III)/Bi(V) and Bi(I)/Bi(III). These attributes are to be used to facilitate a selective organofluorine transfer, a pharmaceutically relevant transformation that is often challenging. The educational portion of this project will reach out to K-12 students, collaborate with local programs and science teachers, and place an emphasis on Native Hawaiians and other traditionally underrepresented minorities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.