SBE-UKRI: Synthetic Genomics and Responsible Research and Innovation

该项目的目的是：(1)对科学家如何设计和构建大范围的DNA进行社会科学分析；(2)在国际、跨项目、多物种的背景下，开发负责任的研究和创新的新方法。合成基因组学是一个新兴的科学领域，科学家们的目标是设计和构建比以往任何时候都更大的DNA片段，在染色体甚至整个基因组的规模上。我们的目标是通过进行社会科学分析，将不同的视角带入这一领域，以支持对负责任研究的讨论。通过在大规模、国际性、协作性的基因组学科学研究中进行负责任的研究，该项目将减少由孤立的社会科学家在个别项目层面组织这些对话的倾向。该项目将对直接从事基因组学和工程生物学工作的科学家以及公民、政策制定者和其他领域的科学家感兴趣。该项目是对合成基因组学的跨国社会科学调查，以促进负责任的研究和创新的理论和实践，并为社会科学和自然科学之间未来富有成效的合作发展能力。它将研究国家竞争力和国际合作的理念如何塑造合成基因组学的政策，以及负责任的研究和创新在这些政策中的地位。它将反思并阐明社会科学在负责任地开展合成基因组学方面可以发挥的作用。该项目将通过一系列讲习班将不同利益攸关方的观点带入合成基因组学的讨论，以调查合成基因组学并发展与该领域的社会科学接触。该项目的发现将有助于负责任的研究和创新(RRI)、研究和资助政策、预期和研究轨迹之间的关系、与科学领域的跨学科合作的挑战以及多物种研究的理论和实践。在创新研究、社会学、人类学、地理学、政治学、发展研究、历史、哲学和生物伦理学方面工作的研究人员将感兴趣。这项建议是根据SBE-UKRI牵头机构机会授予的。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

The aim of this project is: (1) to carry out a social scientific analysis into how scientists design and build large stretches of DNA and (2) to develop new approaches to responsible research and innovation in an international, cross-project, multispecies context. Synthetic genomics is an emerging scientific field in which scientists aim to design and build larger stretches of DNA than ever before, at the scale of chromosomes and even whole genomes. We aim to bring diverse perspectives into this field by conducting a social scientific analysis designed to support discussion of responsible research. By studying responsible research within a large-scale, international, collaborative scientific in genomics this project will mitigate the tendency for these conversations to be organized at the individual project level by isolated social scientists. This project will be of interest to scientists working directly in genomics and engineering biology as well as citizens, policy makers, and scientists working in other fields.This project is a cross-national social scientific investigation of synthetic genomics to further the theory and practice of responsible research and innovation, and to develop capacity for productive future collaborations between the social and natural sciences. It will examine how ideas of national competitiveness and international collaboration are shaping policies for synthetic genomics and the place of responsible research and innovation within these policies. It will reflect on and articulating roles that social sciences can play in doing synthetic genomics responsibly. This project will bring diverse stakeholder perspectives into discussions of synthetic genomics through a series of workshops to investigate synthetic genomics and developing social scientific engagement with the field. The project’s findings will contribute the theories and practices of responsible research and innovation (RRI), research and funding policy, the relationship between expectations and research trajectories, the challenges of interdisciplinary collaboration with scientific fields, and multispecies studies. It will be of interest to researchers working in innovation studies, sociology, anthropology, geography, politics, development studies, history, philosophy and bioethics.This proposal is awarded under the SBE-UKRI Lead Agency Opportunity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.