Modulation of 14-3-3 protein-protein interactions by supramolecular chemistry (B04)

在B4项目中，我们将使用超分子配体来调节14-3-3蛋白的蛋白-蛋白相互作用（PPIs）。这些适配蛋白与人类细胞中200多种伴侣蛋白表现出广泛的相互作用，其中许多与许多人类疾病有关。细胞生物学、生物物理PPI分析和蛋白质晶体学将用于确定A1、A2、A3、A5、A10和A11中开发的调节生物学相关14-3-3功能的超分子配体的作用模式和效力。

In project B4 we will use supramolecular ligands to modulate Protein-Protein Interactions (PPIs) of 14-3-3 proteins. These adapter proteins exhibit an extensive interactome with more than 200 partner proteins in human cells, many of which are associated with a number of human diseases. Cell biology, biophysical PPI analysis, and protein crystallography will be employed to determine the mode-of-action and potency of supramolecular ligands developed in A1, A2, A3, A5, A10 and A11 modulating biologically relevant 14-3-3 functions.