MRI: Acquisition of a New X-Ray Diffractometer to Advance Research and Education in Primarily Undergraduate/Minority Serving Institutions within the District of Columbia

这个奖项给哥伦比亚哥伦比亚特区（UDC）的大学是由主要研究仪器和化学研究仪器计划支持，以支持和改善研究由宋学清博士和同事王磊，Ozlem迪莱克，Uche Udeochu和亚历山德拉Taraboletti。该机构正在购置一台单晶X射线衍射仪。一般来说，X射线衍射仪允许准确和精确地测量分子的完整三维结构，包括键距和角度，并提供关于分子相对于相邻分子的空间排列的准确信息。这里描述的研究影响了许多领域，包括有机和无机化学，材料化学，地质学和生物化学。该仪器是教学的一个组成部分，以及研究和本科生在化学和生物化学研究培训在这个历史悠久的黑人学院和大学（HBCU）以及其他机构在DC地区，如美国天主教大学，美国大学，Gallaudet大学和Trinity华盛顿大学。该仪器为分布在各个部门的各种课程的学生提供直接的研究经验。为期一周的暑期研究所旨在为UDC和合作机构提供正式的晶体学实践培训。X射线衍射仪的奖项旨在加强各级研究和教育。该仪器所支持的科学通过将铜螯合剂cuprizone的金属酶靶点的生物功能和结构研究相关联，并通过探索材料的界面现象和生物重要化合物的结构-活性动力学，提供了相关的社会效益。该仪器还用于研究三有机锡配合物和巯基蛋白酶和荧光探针之间的相互作用，用于成像氧化应激诱导的脂质过氧化产物的巨噬细胞。该衍射仪还被用于进行自旋交叉复合物和基于风化土的地质聚合的原位资源利用的调查。该仪器还为研究抗菌剂、抗病毒剂和脂蛋白代谢调节剂的研究人员，以及分析矿物沉淀技术用于生物介质地基改良的研究人员提供服务。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award to the University of the District of Columbia (UDC) is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs to support and improve research by Dr. Xueqing Song and colleagues Lei Wang, Ozlem Dilek, Uche Udeochu and Alexandra Taraboletti. This institution is acquiring a single crystal X-ray difffractometer (SCXRD). In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry, geology and biochemistry. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this Historically Black College and University (HBCU) as well as the other institution in the DC area such as the Catholic University of America, American University, Gallaudet University and Trinity Washington University. The instrumentation provides direct research experience for students in a variety of courses distributed in various departments. A one-week summer institute is designed to provide UDC and partner institutions formal and hands-on training in crystallography.The award of the X-ray diffractometer is aimed at enhancing research and education at all levels. The science enabled by this instrument provides relevant societal benefits by associating biofunctional and structural studies of the metalloenzymatic targets of the copper chelator cuprizone that inhibits monoamine oxidase and causes liver and brain damage and by exploring interfacial phenomena of materials and structure-activity dynamics of biologically significant compounds. The instrumentation is also used for studying interactions between triorganotin complexes and thiol containing protease and fluorescent probes for imaging oxidative stress-induced lipid peroxidation products of macrophages. The diffractometer is also employed to carry out investigations of spin crossover complexes and regolith-based geopolymerization for in-situ resource utilization. The instrument also serves researchers studying antibacterial, antiviral agents and lipoprotein metabolism modulators and those analyzing mineral precipitation techniques for biomediated ground improvement.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.