H2O2 perception and signal transduction: the specific role of AHK5 (B05)

不同AHK5蛋白结构域的结构有待解决，结构信息与功能研究相结合。这将有助于了解AHK5在体外和体内如何接受过氧化氢或氧化还原条件。用AHK5突变体进行的实验将证明在多大程度上需要组氨酸激酶活性、磷酸化能力和经典Ser/Thr/Tyr磷酸化途径中的串扰来实现AHK5特异的植物反应。此外，还计划在过氧化氢作为信号分子的背景下，确定与AHK5特异的信号和功能有关的其他因素。

The structures of different AHK5 protein domains are to be solved and structural information combined with functional studies. This wil help to understand how the AHK5 peceives H2O2 or redox conditions in vitro and in vivo. Experiments with AHK5 mutants will demonstrate the extent to which histidine kinase activity, phosphorylay capacity, and cross-talk in classical Ser / Thr / Tyr phosphorylation pathways are required for the AHK5-specific plant responses. In addition, the identification of other factors contributing to AHK5-specific signaling and function in the context of H2O2 as a signaling molecule is planned.