I-Corps: Device to prevent blood flow to injured and hemorrhaging blood vessels

这个i-Corps项目的更广泛的影响/商业潜力是开发一种基于外科医生对当前出血控制方法的反馈而设计的救生出血控制装置。目前解决一些出血的方法包括中断腹部大部分和所有下肢的血液供应。移除这些封堵方法可能会导致并发症。这一建议的设备有可能改善美国(和全球)相关的出血发病率和死亡率，并在影响出血干预成功的同时降低与并发症相关的成本。这项I-Corps项目基于复苏血管内搭桥的开发，这是一种临时支架，可以快速有效地闭塞特定区域的血管并控制出血，同时允许血液流向身体其余部分。与目前所有的封堵方法相比，这种拟议的设备增加了医生处理损伤和抢救患者的时间框架，同时降低了与灌流相关的并发症的风险。这项拟议的技术旨在有效解决血液容量的减少问题，而不会影响患者生存所需的重要器官和组织的血液供应。与目前的方法相比，该设备可以在主动创伤的情况下无缝使用，而不会影响患者的预后。此外，该设备还有可能用于其他一些应用，包括局部肢体出血，以及包括野战和军事创伤在内的其他护理环境。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is the development of a lifesaving hemorrhage control device designed based on surgeon feedback on current methods for hemorrhage control. Current methods for addressing some hemorrhages include can involve interrupting blood supply to large portions of the abdomen and all of the lower extremities. Complications can result from the removal of these occlusion methods. This proposed device has the potential to improve the associated morbidity and mortality of hemorrhage in the US (and globally), and reduce the costs associated with complications while impacting the success of hemorrhage intervention.This I-Corps project is based on the development of a resuscitative endovascular bypass, which is a temporary stent that rapidly and effectively occludes vessels and controls hemorrhage in a specific region while allowing blood flow to the remainder of the body. Compared to all current methods of occlusion, this proposed device increases the time frame within which physicians may address injuries and save a patient, while reducing risk of perfusion related complications. The proposed technology is designed to effectively address the reduction of blood volume without compromising blood supply to vital organs and tissues necessary for the patient’s survival. The device may be used seamlessly in an active trauma situation without compromising the outcome of the patient, as compared with current methods. In addition, this device also has the potential to be utilized in a number of other applications, including localized extremity hemorrhage, as well as in additional care settings including field and military trauma.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.