Emergent Properties of Cancer Square Table

该提案寻求对方桌会议（SQT）的支持，该会议是由美国国家癌症研究所（NCI）癌症生物学部（DCB）和美国国家科学基金会（NSF）数学和物理科学理事会（MPS）共同组织的三次会议之一，旨在探索物理科学与数学、合成和系统生物学以及癌症研究的基础研究。会议的目标是促进研究人员之间的讨论，这些研究人员在各自学科的前沿工作可能尚未以实质性的方式交叉，但他们的知识，思想和想法的交流可以确定对癌症研究具有高潜在影响的研究发现和方向，并可能改变癌症研究。本次会议名为“SQT-癌症的突发性特性”，将补充另外两个会议“SQT-活体材料”和“SQT-细胞窗口”。会议的目标是讨论基础科学（通常由美国国家科学基金会数学和物理科学理事会资助）和癌症研究（通常由美国国家癌症研究所资助）之间的基本挑战和机遇，以及可能实现变革性研究的必要方法发展。会议结果将是一份关于会议讨论和提出问题的综合报告。连同其他两个SQT会议的报告，这些报告将提供未来问题的智力地图，并帮助NCI和NSF了解最有趣和最重要的科学交叉点。与生物学相关的物理科学和数学、合成生物学和系统生物学以及癌症研究的最新进展突出表明，需要在10-15年后探索这些领域的交叉点，以寻找新的机会并确定差距。这个方桌（SQT）会议旨在汇集基础科学和数学，合成生物学和癌症研究人员的独特和非相互作用的学科。本次SQT会议将重点关注癌症的紧急特性，是三次会议中的第三次会议，补充了由美国国家癌症研究所（NCI）癌症生物学部（DCB）和美国国家科学基金会（NSF）数学和物理科学理事会（MPS）联合主办的细胞SQT会议上的生命材料和窗口。本次SQT会议还将发起和促进研究小组之间的新伙伴关系，这些研究小组通常不相互作用，但他们各自的研究努力可以补充和促进协同工作，在生物技术和医学领域具有强大的潜在变革性影响。参与者之间的互动和跨学科合作可以为培养下一代科学家、工程师和研究人员提供坚实的基础。会议结果将是一份关于会议讨论和提出问题的综合报告。连同其他两个SQT会议的报告，这些报告将提供未来问题的智力地图，并帮助NCI和NSF了解最有趣和最重要的科学交叉点。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This proposal seeks support for a Square-Table (SQT) meeting that is one of three meetings co-organized by the Division of Cancer Biology (DCB) of the National Cancer Institute (NCI) and the Mathematical and Physical Sciences (MPS) Directorate of the National Science Foundation (NSF) to explore fundamental research at the nexus of the physical sciences and mathematics, synthetic and systems biology, and cancer research. The goal of the meetings is to foster stimulating discussions between researchers whose work at the frontiers of their own discipline may not yet intersect in a substantial way yet but whose exchange of knowledge, thoughts, and ideas could identify research discoveries and directions that have high potential impact on, and may be transformative for, cancer research. This meeting, entitled SQT- Emergent Properties of Cancer, will complement the other two meetings on SQT- Living Materials and SQT- Windows on the Cell. The goal are discussion of fundamental challenges and opportunities at and over the horizon (10-15 year time frame) at the interface between fundamental sciences (typically funded by the Directorate of the Mathematical and Physical Sciences at the NSF) and cancer research (typically funded by NCI) and needed methodological developments that could enable transformative research. The outcome will be a synthesized report of the discussions and questions raised in the meeting. Along with the reports of the other two SQT meetings, these reports will provide an intellectual map of future questions and serve both NCI and NSF to understand the scientific intersections that are most interesting and important. Recent advances in the physical sciences and mathematics relevant to biology, in synthetic and systems biology, and in cancer research have highlighted the need to explore the intersection of these areas at and over the horizon, 10-15 years out, for new opportunities and identifying the gaps. This Square-Table (SQT) meeting is intended to bring together distinct and non-interacting disciplines of the fundamental sciences and math, with synthetic biology, and cancer researchers. This SQT meeting will focus on Emergent Properties of Cancer and is the third of three meetings, complementing Living Materials and Windows on the Cell SQT meetings sponsored jointly between the Division of Cancer Biology (DCB) of the National Cancer Institute (NCI) and the Mathematical and Physical Sciences (MPS) Directorate of the National Science Foundation (NSF). This SQT meeting will also initiate and foster new partnerships between groups of researchers who generally don’t interact but whose separate research endeavors can complement and foster synergistic work with strong potentially transformative impact in biotechnology and medicine. Interactions and interdisciplinary collaborations between the participants can provide a solid ground for training the next generation of scientists, engineers and researchers. The outcome will be a synthesized report of the discussions and questions raised in the meeting. Along with the reports of the other two SQT meetings, these reports will provide an intellectual map of future questions and serve both NCI and NSF to understand the scientific intersections that are most interesting and important.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.