Near the onset of rigidity in living and nonliving matter

生物和非生物物质即将开始僵化

• 批准号: 1507938
• 负责人: Jennifer Schwarz
• 金额: $ 31.5万
• 依托单位: Syracuse University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1507938&HistoricalAwards=false
• 关键词: Near; onset; rigidity; living; nonliving

NONTECHNICAL SUMMARY Have you ever played a game of "Pick up Sticks" and wondered how an entire structure of randomly arranged sticks can collapse with the removal of just one stick? And have you ever wondered how a skin cell changes shape to crawl towards a wound to heal it? The notion of the onset of mechanical rigidity in both living and nonliving matter will help answer both of these seemingly disparate questions. To explore the emergence (and destruction) of mechanical rigidity in nonliving matter, the proposed modeling will be based on a collection of frictionless, repulsive soft spheres; while in living matter, it will utilize a disordered spring network. The PI's group will test both models by investigating what properties - friction, particle/filament shape, type of crosslinking between filaments, local mechanical stability - affect the nature of the rigidity transition. These models will be used to describe mechanical stability of two- and three-dimensional systems including granular systems, filamentous cytoskeletal networks, and biological tissue in the brain. The proposed work, therefore, extends the reach of materials science to living systems to help drive the emerging field of quantitative biology. The results of the proposed research will be used for development of a new course material on rigidity in both living and nonliving systems at undergraduate and graduate levels. The proposed collaborations with Syracuse Museum of Science and Technology and the YWCA will educate the public about the intrigue of soft matter. The PI will use her knowledge and experience to recruit women to the physical sciences by presenting scientific advances used to decouple the biological clock and the tenure clock to senior graduate students and post-docs. TECHNICAL SUMMARY How does a collection of randomly packed frictional particles at the threshold of mechanical rigidity destabilize with the deletion of just one contact? And how does a collection of cytoskeletal filaments attain mechanical rigidity to extend the reach of a cell? In nonliving matter, the model will be based on a collection of frictionless, repulsive soft spheres; while in living matter, it will utilize a disordered spring network. The PI's group will test the robustness of both models by investigating what properties - friction, particle/filament shape, type of crosslinking between filaments, local mechanical stability - affect the nature of the rigidity transition. To test for this robustness in nonliving systems, the local properties of mechanical stability at the onset of rigidity for frictionless, repulsive soft discs in two dimensions will be studied by using concept of jamming graph. Armed with the information of constraint counting, geometry, and force-balance, the PI's group will develop a model for the onset of rigidity in frictionless, particulate matter. The emergence (and destruction) of rigidity abounds in living matter as well. The actin filament cytoskeletal network adjusts its morphology to support the cell structurally. The proposed research will narrow the existing theoretical gap between morphology and mechanics by building disordered spring network models that encode more of the network morphology, such as anisotropy and angle-constraining crosslinks, to determine which aspects are more relevant to the onset of rigidity than others. Moreover, quantitative modeling of biological tissue in the brain will be developed using vertex models, which are related to disordered spring networks. The PI's group will investigate the interplay between morphology and mechanics to determine how glial cells structurally support bundles of neurons. The results of the proposed research will be used for development of a new course material on rigidity in both living and nonliving systems at undergraduate and graduate levels. The proposed collaborations with Syracuse Museum of Science and Technology and the YWCA will educate the public about the intrigue of soft matter. The PI will be involved in the recruitment of women to the physical sciences by presenting scientific advances used to decouple the biological clock and the tenure clock to senior graduate students and post-docs.

你是否曾经玩过一个“捡起棍子”的游戏，想知道一个随机排列的棍子的整个结构是如何随着一根棍子的移动而倒塌的？你有没有想过皮肤细胞是如何改变形状爬向伤口来愈合的？ 在生命和非生命物质中开始出现机械刚性的概念将有助于回答这两个看似完全不同的问题。为了探索非生命物质中机械刚性的出现（和破坏），所提出的建模将基于一组无摩擦、排斥性的软球体;而在生命物质中，它将利用无序的弹簧网络。PI的团队将通过研究什么性质-摩擦，颗粒/细丝形状，细丝之间的交联类型，局部机械稳定性-影响刚性转变的性质来测试这两种模型。这些模型将用于描述二维和三维系统的机械稳定性，包括颗粒系统，丝状细胞骨架网络和生物组织在大脑中。因此，拟议的工作将材料科学的范围扩展到生命系统，以帮助推动新兴的定量生物学领域。 拟议的研究结果将用于开发一个新的课程材料刚性在生命和非生命系统在本科和研究生阶段。拟议中的与锡拉丘兹科技博物馆和基督教女青年会的合作将教育公众关于软物质的阴谋。PI将利用她的知识和经验，通过向高年级研究生和博士后展示用于分离生物钟和终身制时钟的科学进步，招募女性进入物理科学领域。在机械刚性阈值处随机堆积的摩擦颗粒的集合如何在仅删除一个接触的情况下不稳定？一组细胞骨架丝是如何获得机械刚度来扩展细胞的范围的？在非生命物质中，该模型将基于一组无摩擦、排斥的软球体;而在生命物质中，它将利用无序的弹簧网络。PI的团队将通过研究什么性质-摩擦、颗粒/细丝形状、细丝之间的交联类型、局部机械稳定性-影响刚性转变的性质来测试两种模型的稳健性。为了测试这种鲁棒性在非生命系统中，局部性质的机械稳定性在刚性的无摩擦，排斥性的软磁盘在两个维度上将研究通过使用干扰图的概念。有了约束计数，几何形状和力平衡的信息，PI的小组将开发一个模型，用于在无摩擦的颗粒物质中开始刚性。刚性的出现（和毁灭）也在生命体中比比皆是。肌动蛋白丝细胞骨架网络调整其形态以在结构上支持细胞。拟议的研究将缩小形态学和力学之间现有的理论差距，通过建立无序的弹簧网络模型，编码更多的网络形态，如各向异性和角度约束交联，以确定哪些方面比其他方面更相关的刚度。此外，将使用与无序弹簧网络相关的顶点模型来开发大脑中生物组织的定量建模。PI的小组将研究形态学和力学之间的相互作用，以确定神经胶质细胞如何在结构上支持神经元束。拟议的研究结果将用于开发一个新的课程材料刚性在生命和非生命系统在本科和研究生阶段。拟议中的与锡拉丘兹科技博物馆和基督教女青年会的合作将教育公众关于软物质的阴谋。PI将通过向高年级研究生和博士后介绍用于分离生物钟和终身制时钟的科学进步，参与招聘物理科学领域的妇女。