2021 Virtual International Mammalian Synthetic Biology Workshop (mSBW)

哺乳动物合成生物学是设计遗传装置，使研究和控制哺乳动物细胞中的生物过程成为可能。哺乳动物合成生物学提供了工具和设计策略，以加速各种疗法的进步;因此，许多正在开发的技术将在长期内用于最终的医疗用途。2021年虚拟国际哺乳动物合成生物学研讨会（mSBW）将重点介绍该领域的进展和最先进的技术，并鼓励学生参与，以培养新一代工程师。会议的资金还将支持工程领域代表性不足的群体出席会议。2021年虚拟国际哺乳动物合成生物学研讨会（mSBW）的目标是聚集在哺乳动物合成生物学工作的各个职业阶段的科学家和工程师社区，以突出新的技术进步。该项目旨在将工程科学与生命科学相结合，鼓励多学科领域的研究和开发，教育下一代年轻科学家，帮助转化科学，并支持前沿研究以应对当前和未来的挑战。该研讨会将强调新的计算工具/方法，以帮助预测和定量研究系统的行为。从长远来看，基础科学、工程技术和计算模型的进步对医药产品的开发至关重要，因为它有助于改善对疾病的理解、监测和治疗。研讨会将包括五个技术会议：（1）基础进展，（2）在干细胞中的应用，（3）免疫治疗和细胞治疗，（4）基因调控，（5）传感器和多输入逻辑。研讨会还将举办几个问答讨论，网络休息，以及海报会议，让学生展示他们的工作。我们希望，各种网络机会将使与会者能够讨论所提出的最先进的技术，并希望讨论将导致可能加速该领域发展的潜在合作。即将发表的白色论文将突出讨论的要点，并允许更广泛的科学界对讨论的新进展进行深入了解。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Mammalian synthetic biology is the design of genetic devices that enables the study and control of biological processes in mammalian cells. Mammalian synthetic biology provides the tools and design strategies to accelerate the advancement of various therapies; therefore, many of the technologies being developed will be useful for eventual medical use in the long term. The 2021 Virtual International Mammalian Synthetic Biology Workshop (mSBW) will highlight the advances in the field and state-of-the-art technologies developed, as well as encouraging the participation of students in order to train a new generation of engineers. Funding for the conference will also support the attendance of underrepresented groups in engineering. The goal of the 2021 Virtual International Mammalian Synthetic Biology Workshop (mSBW) is to congregate the community of scientists and engineers at various career stages working on mammalian synthetic biology to highlight new technological advances. The project will aim to integrate the engineering sciences with the life sciences, encouraging research and development in multidisciplinary areas, educating the next generation of young scientists, aiding translational science, and supporting cutting edge research to answer current and future challenges. The workshop will emphasize novel computational tools/methods to aid in predicting and quantitatively studying system behavior. The advances in fundamental science, engineering techniques, and computation models will be critical for the development of medicinal products in the long term as it will be useful for improving understanding, monitoring, and treatment of disease. The workshop will contain five technical sessions: (1) Foundational advances, (2) Applications in stem cells, (3) Immunotherapy and cell therapy, (4) Gene regulation, (5) Sensors and multi-input logic. The workshop will also host several Q&A discussions, networking breaks, as well as poster sessions that allow students to present their work. It is our hope that the various networking opportunities will give the attendees the ability to discuss the state-of-the-art technology being presented, and that the discussions will lead to potential collaborations that may accelerate development in the field. The white paper that will be published will highlight the main points of the discussions, and allow for the broader scientific community to gain insight regarding the new advances discussed.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.