SBIR Phase I: A CPR-integrated airway and ventilator system that eliminates human operator variability

这个小型企业创新研究（SBIR）第一阶段项目的更广泛的影响/商业潜力是在紧急情况下实现自动心脏复苏。心肺复苏（CPR）是一个手动过程，取决于响应者的技能。通气，将空气正确输送到患者的气道中，是CPR期间需要最多技能的过程，并且因为它是手动完成的，所以是最可变的-特别是在高压力环境中。所提出的自动化系统提供了一种方便、可靠的进入气道的方式，其自动地通过胸外按压进行通气，以改善CPR期间的血液循环。该系统还在气道导管中引入了除颤电极，以在更低、更安全的电压下实现心脏除颤。 SBIR第一阶段项目开发了一种新型的自动化系统，可为患者提供方便、可靠的通气和同步按压。该项目的技术里程碑旨在证明：（A）与当前解决方案相比，在猪模型中降低气道放置过程中的操作员变异性并改善氧气供应，（B）根据气道中测量的压力变化可靠地检测心脏收缩，以及（C）在尸体模型中以较低能量进行电除颤的可行性。技术挑战是：考虑人体解剖结构的变化并检测插入气道的错误，考虑系统未检测到的胸部按压，该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查进行评估，被认为值得支持的搜索.

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is enabling automated cardiac resuscitation in emergency situations. Cardiopulmonary Resuscitation (CPR) is a manual process dependent on responder skills. Ventilation, the proper delivery of air into the patient’s airways, is the process during CPR that requires the most skill and, because it is manually accomplished, is the most variable - especially in high stress environments. The proposed automated system offers a convenient, reliable way of accessing the airway which automatically synchronizes ventilation with chest compressions to improve blood circulation during CPR. The system also introduces a defibrillation electrode in the airway tube to enable cardiac defibrillation at lower, safer voltages. This SBIR Phase I project develops a novel, automated system to provide convenient, reliable patient ventilation and synchronization of compressions. The project’s technical milestones are to demonstrate: (A) reduced operator variability during airway placement and improved oxygen supply in swine models compared to current solutions, (B) reliable detection of cardiac contractions from pressure changes measured in the airway, and (C) feasibility of electric defibrillation with lower energy in cadaver models. The technical challenges are to: account for variations in human anatomy and detect errors with insertion into the airway, account for chest compressions not detected by the system, and ensure electrical contact between the defibrillation electrode and the esophagus during cardiac defibrillation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.