SBIR Phase I: Neuromodulation device to promote healthy sleeping cycle

这项小型企业创新研究（SBIR）第一阶段项目旨在提供一种安全的可穿戴设备，以改善睡眠质量。由于失眠或其他因素导致的睡眠剥夺代表着与各种日常问题和生活中的后期障碍相关的重大健康风险。据估计，睡眠不足使美国损失了4110亿美元的生产力和工资。这项新的医疗技术将提供一种外部佩戴的系统，该系统提供低风险和可逆的视觉和听觉脉冲的组合，使患者能够体验与所需的恢复性睡眠阶段相关的脑电波。该产品旨在占据每年800亿美元的全球睡眠辅助市场的重要部分，主要由补充剂和药物组成。该小型企业创新研究（SBIR）第一阶段项目将完成患者佩戴系统的原型工程，该系统提供感官刺激，以调节睡眠期间的脑波形。该系统利用受控和安全的光和声音刺激，将与所需睡眠状态相关的脑波转换到接受者的大脑中，使用非侵入性电活动（EEG）进行测量。该系统基于同行评审的证据，即正常的脑电波模式可以有效地转移到患有睡眠障碍的受试者身上，以恢复正常睡眠。第一阶段项目将完成参考患者睡眠模式的数据分析，以及原型设计工程，以便在后续阶段进行试点研究并获得证据。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。

This Small Business Innovation Research (SBIR) Phase I project aims to provide a safe, wearable device to to improve the quality of sleep. Sleep deprivation due to insomnia or other factors represents a significant health risk linked to various daily issues and later disorders in life. The lack of sleep costs the United States an estimated $411 billion in lost productivity and wages. This novel medical technology will provide an externally worn system which delivers a combination of low risk and reversible visual and auditory impulses, enabling patients to experience brainwaves associated with the desired restorative sleep stage. The product aims to capture a significant portion of the annual $80B global sleep aid market predominantly comprised of supplements and drugs. This Small Business Innovation Research (SBIR) Phase I project will complete prototype engineering for a patient worn system which provides sensory stimulation in order to modulate brain waveforms during sleep. The system utilizes controlled and safe light and sound stimuli to transpose the brainwaves associated with the desired sleeping state into the recipient’s brain measured using non invasive electrical activity (EEG). The system is based on peer-reviewed evidence that normal brain wave patterns can be effectively transposed to a subject suffering from sleep disorders for restoring normative sleep. The phase I project will complete the data analysis of reference patient sleep patterns, and prototype design engineering to enable pilot studies and gaining evidence in subsequent stages.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.