Synthetic and Mechanistic Studies on Ni-catalysed Benzannulation Reactions

芳香族化合物在科学和公共环境的各个方面发挥着主导作用（例如天然和智能材料）。因此，该提议寻求使炔的Ni催化的环加成生长为用于合成硼酸酯的有效且原子经济的方法，硼酸酯是用于形成芳族和类似杂环化合物的合成强有力的组分。该方法的显著优点是使用相对简单的起始原料，这允许构建复杂的和高度取代的结构。主要地，Ni催化的环丁烯酮苯并环化的反应机理应该通过使用供体官能化的炔来建立。有了这些机制的见解，基板，提供一贯的高水平的区域选择性的苯并环化反应应设计。最后，镍催化反应的可用工具箱应该显著扩展到芳香族和类似杂环硼酸酯（例如，苯并环化反应）。G.含氮或氧的羰基化合物），其还没有通过过渡金属催化制备。由于其下游化学的多样性，将特别关注使用当前方法无法获得的多环化合物的制备。

Aromatic compounds play a leading role in all aspects of the scientific and common environment (e.g. natural and smart materials). Therefore, this proposal seeks to grow Ni-catalysed cycloadditions of alkynes as an efficient and atom economic method for the synthesis of boronates, which are synthetically powerful components for the formation of aromatic and analogous heterocyclic compounds. The remarkable advantage of this process is the use of relatively simple starting materials which allow to construct complex and heavily substituted structures.Predominantly, the reaction mechanism of the Ni-catalysed benzannulation of cyclobutenones should be established by using donor functionalized alkynes. With these mechanistic insights, substrates that offer consistently high levels of regioselectively in the benzannulation reaction should be designed. This step would be a key milestone for Ni-catalysed benzannulation.Finally, the available toolbox of Ni-catalysed reactions should be significantly expanded to aromatic and analog heterocyclic boronates (e. g. carbonyl compounds containing nitrogen or oxygen) which have not yet been prepared by transition metal catalysis. Due to their manifold downstream chemistry a particular focus will be on the preparation of polycyclic compounds that cannot be accessed using the current methodology.