Cavity-Containing Supramolecular Gels as a Tool for Orthogonal Self-assembly Crystallization Processes

本项目的目的是建立正交自组装结晶过程，其中凝胶剂和结晶体系形成弱耦合排列。这种非平衡正交自组装结晶技术提供了巨大的优势，因为它提供了暴露的凝胶纤维的高表面积，其中晶体生长是通过扩散和成核控制的过程进行的。为此，我们将合成含有碗状分子的新型低相对分子质量超分子凝胶，并研究它们的凝胶形成行为及其在外界刺激下的可逆性。这些凝胶将用于正交自组装结晶过程，通过利用凝胶纤维的活性表面来控制药物固体形态的成核，有可能成为药物多晶型筛选的新工具。

The aim of this project is to establish orthogonal self-assembly crystallization processes in which gelator and crystallization system form a weakly coupled arrangement. This technique of non-equilibrium orthogonal self-assembly crystallization offers great advantages as it provides a high surface area of exposed gel fibres where the crystal growth occurs through a diffusion and nucleation-controlled process. For these new low molecular weight supramolecular gels containing bowl-shaped molecules will be synthesized and their gel formation behavior as well as its reversibility by external stimuli will be studied. These gels will be engaged for orthogonal self-assembly crystallization processes which have the potential to become a new tool in pharmaceutical polymorph screening by use of the active surface of the gel fibres to control the nucleation of the drug solid form.