CAS: Dialing-In Sonochemical Synthesis of Transition Metal Precatalysts

在化学系化学合成（SYN）项目的支持下，中央佛罗里达大学化学系的Titel Jurca正在开发可持续的方法来合成化学工业中用作催化剂的金属化合物。催化剂是可以加速化学反应的物质，对于减少许多重要过程中的消耗和废物形成至关重要。然而，催化剂本身通常以环境不友好的方式制备。该项目的重点是利用超声波辐射在一个单步过程中产生催化剂，使用传统制备所需的溶剂，时间和能量输入的一小部分。在该计划下培训的学生将获得最先进的化学技术的专业知识。此外，他们还将接受绿色和可持续技术培训，培养评估和设计可持续化学工艺方面的专门知识，该项目将为广泛使用的席夫碱配体及其配位络合物的超声波辅助合成制定规程。该项目有五个主要目标：（i）描述温度、声强、浓度和覆盖气体对一锅法超声化学合成双（亚氨基）吡啶配体、-二亚胺及其相应过渡金属化合物的影响;（ii）将反应方案扩展到非对称双（亚氨基）吡啶配体、-二亚胺及其相应过渡金属化合物的超声化学合成;（iii）开发用于栓系的多齿配体和非栓系的过渡金属络合物的一锅法声化学路线;（iv）利用在先前任务中合成的预催化剂优化用于催化硼氢化的声化学条件;以及（iv）评估声化学与常规基于溶液的合成的绿色化学度量。在研究目标的同时，PI将致力于为下一代催化科学家制定培训和推广计划，重点是为服务不足的少数民族社区成员提供机会。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With the support of the Chemical Synthesis (SYN) Program of the Chemistry Division, Titel Jurca of the Department of Chemistry at the University of Central Florida is developing sustainable ways to synthesize metal compounds that are used as catalysts by the chemical industry. Catalysts are species that can accelerate chemical reactions and are critical for reducing consumption and waste formation during many important processes. However, the catalysts themselves are often prepared in an environmentally unfriendly fashion. This project focuses on utilizing ultrasonic irradiation to generate catalysts in a single-step process using a fraction of the solvent, time, and energy input required for the conventional preparations. Students trained under this program will gain expertise in state-of-the-art chemical techniques. In addition, they will be trained in green and sustainable technologies, where they will develop expertise in the assessment and design of sustainable chemical processes.This project will develop protocols for the ultrasonic-assisted synthesis of broadly utilized Schiff-base ligands, and their coordination complexes. The project has five key aims: (i) to delineate the effects of temperature, acoustic intensity, concentration, and cover gas for the one-pot sonochemical synthesis of bis(imino)pyridine ligands, -diimine, and their respective transition metal compounds; (ii) to extend the reaction protocols towards the sonochemical synthesis of non-symmetric bis(imino)pyridine ligands, -diimine and their respective transition metal compounds; (iii) to develop one-pot sonochemical routes for tethered, multi-dentate ligands and bimetallic transition metal complexes; (iv) to optimize the sonochemical conditions for catalytic hydroboration utilizing the precatalysts synthesized in the previous tasks and (iv) to assess the green chemistry metrics for sonochemical vs. conventional solution-based synthesis. In parallel to the research goals, the PI will work to develop a training and outreach program for the next generation of catalysis scientists, with a focus on providing opportunities to members of underserved minority communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.