Role of Ena/VASP proteins in vessel branching and vascular repair (A08)

我们已经证明了Ena/Vasp蛋白在白细胞-内皮细胞通讯、血管生成和血管修复中的重要作用。然而，Ena/Vasp蛋白在动脉粥样硬化等病理条件下的潜在分子机制和作用尚不清楚。在这里，我们的目标是确定ENA/Vasp调节的受体运输和引导信号在血管生成和动脉粥样硬化中的分子机制和生理相关性。

We have demonstrated an important role of the Ena/VASP proteins in leukocyte-endothelial cell communication, angiogenesis and vascular repair. However, underlying molecular mechanisms and the role of the Ena/VASP proteins in pathologic conditions, such as atherosclerosis, are elusive. Here, we aim to determine the molecular mechanisms and the physiological relevance of Ena/VASP-regulated receptor trafficking and guidance cue signalling in angiogenesis and atherosclerosis.