The significance of adverse experience, emotional processing and body perception for pseudoneurological symptoms

无神经学来源的神经系统症状(如运动、感觉或视力障碍)称为假性神经症状(PNS)。慢性病的高风险、心理压力和由此对卫生系统造成的负担定义了它们的临床相关性。然而，治疗结果不充分，这在一定程度上可以归因于诊断和病因清晰度不够。总体的长期目标是促进对PNS的更准确的评估，计划项目的主要目标是检查PNS的假设模型，即PNS被描述为躯体形式(与精神形式)分离，结果是(早期，主要)情绪逆境和虐待的相互作用，随后情绪和生物系统断开。情绪加工对述情障碍和习惯性情绪抑制的不平衡增加了注意力对内感的关注，特别是在情绪压力之后。我们将在一系列研究中检验这一模型，包括(1)自我评估(问卷，访谈)，(2)心理生理学和行为实验(处理对情绪刺激和情绪调节的自动反应的电磁关联，并在调节内感注意力时检测外感觉阈值)，以及(3)将早期不利经历及其情绪方面重新整合到自传体记忆中的实验干预。

Neurological symptoms (such as movement-, sensibility- or sight-disorders) without neurologically determined origin are called pseudoneurological symptoms (PNS). A high risk for chronicity, psychological strain and consequent burden on the health system define their clinical relevance. However, treatment outcome is insufficient, which can be partly attributed to insufficient diagnostic and etiological clarity. With the overall long-term goal to contribute to more precise assessment of PNS the primary goal of the planned project is to examine the hypothetical model that PNS, characterized as somatoform (vs. psychoform) dissociation, results from an interplay of (early, predominantly) emotional adversities and abuse, with subsequent disconnection of emotional and biological systems. An imbalance in emotion processing towards alexithymia and habitual emotion suppression augments attentional focus on interoception, particularly following emotional stress. We will examine this model in a series of studies including (1) self-assessment (questionnaires, interview), (2) psychophysiological and behavioral experiments (addressing electromagnetic correlates of automatic responses to emotional stimuli and emotion regulation, and examining exteroceptive threshold upon modulation of interoceptive focus of attention), and (3) an experimental intervention re-integrating early adverse experiences and their emotional aspects into autobiographical memory.