Trio Analysis of Recurrent Pregnancy Loss Integrated Bioinformatics Genomics Study (TRIOS)
复发性流产综合生物信息学基因组学研究 (TRIOS) 的三重奏分析
基本信息
- 批准号:10772396
- 负责人:
- 金额:$ 21.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-15 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdvertisementsAffectAnatomyBiochemicalBioinformaticsBiomedical ResearchCaliforniaCatchment AreaChromosome abnormalityChromosomesClassificationClinicalCollectionCommunitiesCommunity HealthcareCommunity OutreachCommunity PhysicianComplexCounselingCouplesDNADataDatabasesDiagnosticDisciplineDiseaseDisparityDissemination and ImplementationEducationEligibility DeterminationEnrollmentEnsureEquityEthnic OriginEtiologyEvaluationFamilyFocus GroupsFrustrationFundingFutureGeneticGenetic DiseasesGenetic MedicineGenetic Predisposition to DiseaseGenetic ResearchGenetic VariationGenetic studyGenomicsGeographyGoalsHealthHealth PersonnelHealthcare SystemsHematologyHeritabilityHispanicHomeHumanHuman BiologyHuman GeneticsIndividualInequityLanguageLatinxLatinx populationMachine LearningMedicineMethodologyMethodsParentsParticipantPatient CarePatientsPerinatalPersonsPhasePopulationPopulation HeterogeneityPositioning AttributePrecision HealthPregnancy OutcomePregnancy lossPrenatal careProviderRaceRecommendationRecurrenceReduce health disparitiesReproductive MedicineResearchRiskSeminalSiteSpontaneous abortionTest ResultTestingTransportationUnderrepresented PopulationsVariantWorkadverse pregnancy outcomebilingualismcohortcommunity engaged researchcommunity engagementcostdemographicsdisparity reductiondiversity and inclusionearly pregnancyeligible participantepidemiology studyethnic diversityexperiencefamily supportgaps in accessgenetic testinggenetic variantgenome sequencinghealth disparityhealth inequalitieshuman diseaseimprovedinnovationinsightlearning strategymachine learning methodminority engagementmultiple omicsnovelnovel therapeuticsonline resourceoutreachparent grantpatient populationpersonalized careracial diversityrecruitreproductiveresearch studyrisk mitigationsample collectionsocioeconomicstherapeutic developmentvariant of unknown significance
项目摘要
PROJECT SUMMARY
Recurrent pregnancy loss (RPL) affects up to 5% of families, yet nearly half of cases remain unexplained after
evaluation by current testing recommendations. Unexplained euploid RPL is particularly frustrating for families
and providers because there is no clear explanation nor proven therapy to mitigate risk of recurrence. As
clinical presentations, subsequent pregnancy outcomes, and underlying etiologies vary widely, this complex
disorder requires a precision health approach. TRIOS, the parent grant, investigates genetic causes of
unexplained recurrent pregnancy loss. Genome sequencing holds immense promise for discovery of genetic
variants that are lethal in humans; however, despite genetic diversity among humankind, it is well-documented
that genetic studies of human disease have historically failed to capture this variation. Repeated
underrepresentation of individuals of non-European ancestry has not only severely limited the understanding of
genetic disease in humans, but has also led to significant ancestry-based health inequities. Conversely,
increased diversity in genomic research has been shown to simultaneously increase genetic discovery and
reduce health disparities. For this reason, concerted efforts to increase racial and ethnic diversity in genetic
research is necessary for discovery and characterization of all disease-causing genetic variants, as well as
providing equitable and personalized care to all. This supplemental proposal aims to explore and implement
novel community outreach, recruitment, and enrollment methods to reduce barriers and increase minority
engagement in the genetic research described in our parent grant. We will engage community physicians and
front-line community healthcare workers through unstructured focus groups to better understand the threats
and opportunities in enrolling their patients in research studies. Financial and transportation barriers will be
minimized by facilitating enrollment and collection of samples by mail. Additionally, we will ensure research
materials are accessible in Spanish, and bilingual staff are available to support families throughout all study
phases. When found, we will provide actionable genetic test results to enrollees, providing personalized and
direct benefit from participation in our research. Importantly, this proposed supplement will provide valuable
insights into best practices for expanding geographic, socio-economic, and ancestral diversity in reproductive
and genetic research. We are uniquely positioned to achieve the aims of this study due to the diverse
population of Northern California, our affiliation with a far-reaching healthcare system, and a research team
experienced in community-engaged research efforts. The proposed supplement is anticipated to enhance and
enrich our recruitment of diverse populations for our parent grant examining genetic causes of RPL through
genome sequencing, multi-omics analysis, and applied machine learning methodologies. This work will
ultimately advance our understanding of RPL, inform human biology, decrease disparities, and allow for
tailored diagnostics, recurrence risks, and novel therapeutics for this devastating and complex disorder.
项目摘要
复发性流产(RPL)影响多达5%的家庭,但近一半的病例在治疗后仍然无法解释。
根据当前的测试建议进行评估。不明原因的整倍体RPL对家庭来说特别令人沮丧
和供应商,因为没有明确的解释,也没有经过验证的治疗,以减轻复发的风险。作为
临床表现,随后的妊娠结局和潜在病因差异很大,这一复杂的
需要采取精确的健康方法。TRIOS,父母补助金,调查遗传原因,
不明原因的反复流产基因组测序为发现遗传物质提供了巨大的希望。
在人类中是致命的变异;然而,尽管人类的遗传多样性,它是有据可查的
人类疾病的遗传学研究历来未能捕捉到这种变异。重复
非欧洲血统的个人代表性不足不仅严重限制了对
这不仅是人类遗传疾病的主要原因,而且也导致了基于祖先的严重健康不平等。相反地,
基因组研究中的增加的多样性已被证明同时增加了遗传发现,
减少健康差距。因此,应共同努力,增加遗传学中的种族和族裔多样性,
研究对于发现和表征所有致病遗传变异是必要的,
为所有人提供公平和个性化的护理。本补充建议旨在探讨和实施
新颖的社区外展、招募和入学方法,以减少障碍,增加少数族裔
参与我们的母基金中描述的遗传研究。我们将聘请社区医生,
通过非结构化的焦点小组,前线社区卫生保健工作者更好地了解威胁
以及让患者参与研究的机会。金融和交通障碍将是
通过方便登记和通过邮件收集样本来最小化。此外,我们将确保研究
材料是西班牙语,双语工作人员可在整个研究支持家庭
阶段。一旦发现,我们将提供可操作的基因测试结果,注册,提供个性化和
直接受益于参与我们的研究。重要的是,这一拟议补充将提供宝贵的
深入了解扩大生殖领域地理、社会经济和祖先多样性的最佳做法
和基因研究。我们处于独特的地位,以实现本研究的目标,由于多样化的
北方加州的人口,我们与一个影响深远的医疗保健系统的联系,以及一个研究团队
在社区参与的研究工作经验。预计拟议补编将加强和
丰富我们的招募不同的人群,为我们的父母补助金检查RPL的遗传原因,通过
基因组测序、多组学分析和应用机器学习方法。这项工作将
最终推进我们对RPL的理解,告知人类生物学,减少差异,并允许
定制的诊断,复发风险和新的治疗方法,这种毁灭性的和复杂的疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ruth B Lathi其他文献
Ruth B Lathi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ruth B Lathi', 18)}}的其他基金
Trio Analysis of Recurrent Pregnancy Loss Integrated Bioinformatics Genomics Study (TRIOS)
复发性流产综合生物信息学基因组学研究 (TRIOS) 的三重奏分析
- 批准号:
10225966 - 财政年份:2021
- 资助金额:
$ 21.62万 - 项目类别:
Trio Analysis of Recurrent Pregnancy Loss Integrated Bioinformatics Genomics Study (TRIOS)
复发性流产综合生物信息学基因组学研究 (TRIOS) 的三重奏分析
- 批准号:
10405508 - 财政年份:2021
- 资助金额:
$ 21.62万 - 项目类别:
Trio Analysis of Recurrent Pregnancy Loss Integrated Bioinformatics Genomics Study (TRIOS)
复发性流产综合生物信息学基因组学研究 (TRIOS) 的三重奏分析
- 批准号:
10612433 - 财政年份:2021
- 资助金额:
$ 21.62万 - 项目类别:
3/3- A randomized controlled trial of frozen embryo transfers performed in modified natural versus programmed cycles (NatPro)
3/3- 冷冻胚胎移植的随机对照试验,以改良的自然周期与程序周期进行(NatPro)
- 批准号:
10025597 - 财政年份:2019
- 资助金额:
$ 21.62万 - 项目类别:
3/3- A randomized controlled trial of frozen embryo transfers performed in modified natural versus programmed cycles (NatPro)
3/3- 冷冻胚胎移植的随机对照试验,以改良的自然周期与程序周期进行(NatPro)
- 批准号:
10682513 - 财政年份:2019
- 资助金额:
$ 21.62万 - 项目类别:
3/3- A randomized controlled trial of frozen embryo transfers performed in modified natural versus programmed cycles (NatPro)
3/3- 冷冻胚胎移植的随机对照试验,以改良的自然周期与程序周期进行(NatPro)
- 批准号:
10247787 - 财政年份:2019
- 资助金额:
$ 21.62万 - 项目类别:
相似海外基金
Content analysis of advertisements and news of skin-lightening products targeting black women and community outreach program
针对黑人女性的美白产品广告和新闻的内容分析和社区外展计划
- 批准号:
10746258 - 财政年份:2023
- 资助金额:
$ 21.62万 - 项目类别:
Collaborative Research: Understanding the Evolution of Political Campaign Advertisements over the Last Century
合作研究:了解上个世纪政治竞选广告的演变
- 批准号:
2148202 - 财政年份:2022
- 资助金额:
$ 21.62万 - 项目类别:
Standard Grant
Collaborative Research: Understanding the Evolution of Political Campaign Advertisements over the Last Century
合作研究:了解上个世纪政治竞选广告的演变
- 批准号:
2147635 - 财政年份:2022
- 资助金额:
$ 21.62万 - 项目类别:
Standard Grant
Collaborative Research: Understanding the Evolution of Political Campaign Advertisements over the Last Century
合作研究:了解上个世纪政治竞选广告的演变
- 批准号:
2148928 - 财政年份:2022
- 资助金额:
$ 21.62万 - 项目类别:
Standard Grant
Examining the Mechanisms Underlying the Influence of Facebook Food Advertisements on Adolescents' Eating Behaviors: Randomized Controlled Trials
检查 Facebook 食品广告对青少年饮食行为影响的机制:随机对照试验
- 批准号:
10188966 - 财政年份:2021
- 资助金额:
$ 21.62万 - 项目类别:
Examining the Mechanisms Underlying the Influence of Facebook Food Advertisements on Adolescents' Eating Behaviors: Randomized Controlled Trials
检查 Facebook 食品广告对青少年饮食行为影响的机制:随机对照试验
- 批准号:
10434838 - 财政年份:2021
- 资助金额:
$ 21.62万 - 项目类别:
Examining the Mechanisms Underlying the Influence of Facebook Food Advertisements on Adolescents' Eating Behaviors: Randomized Controlled Trials
检查 Facebook 食品广告对青少年饮食行为影响的机制:随机对照试验
- 批准号:
10653828 - 财政年份:2021
- 资助金额:
$ 21.62万 - 项目类别:
Advancing machine learning applications for decoding gendered language in job advertisements.
推进机器学习应用程序以解码招聘广告中的性别语言。
- 批准号:
540068-2019 - 财政年份:2019
- 资助金额:
$ 21.62万 - 项目类别:
University Undergraduate Student Research Awards
Consumer Information Processing from Advertisements: Avoidance, Memory, and Attitudes
广告中的消费者信息处理:回避、记忆和态度
- 批准号:
19K13833 - 财政年份:2019
- 资助金额:
$ 21.62万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
POSITIONING OF HEALTH CARE SERVICE: EXAMINATION OF THE ADVERTISEMENTS AND STAKEHOLDER PERCEPTIONS
医疗保健服务的定位:广告检查和利益相关者的看法
- 批准号:
1759113 - 财政年份:2018
- 资助金额:
$ 21.62万 - 项目类别:
Standard Grant