Circuits underlying sparse population coding in the auditory cortex (B18)

在之前的资助期间，我们验证了有争议的观点，即小鼠初级听觉皮质的频率组织在所有层中都是不同的，并进一步在所有层中发现了一个“超反应”神经元的子集。目前的项目将测试这样一种假设，即同质兴奋和局部异质抑制的相互作用塑造了锥体神经元的响应场，创造了神经元反应的异质性景观，并且点缀在这一景观中的超级反应神经元形成了一类特殊的神经元，其输入输出关系与它们的邻居不同。

During the preceding funding period we verified the controversial suggestion that the frequency organization of mouse primary auditory cortex is heterogeneous throughout all layers, and furthermore identified a subset of 'super-responding' neurons in all layers. The current project will test the hypothesis that an interplay of homogeneous excitation and locally heterogeneous inhibition sculpts the response fields of pyramidal neurons, creating the heterogeneous landscape of neuronal responses, and that the super-responding neurons dotting this landscape form a special class of neurons with input-output relationships that are different from those of their neighbors.